NUMT

NUMT is a software pipeline designed to identify nuclear inserts of mitochondrial DNA (NUMTs) originating from archaic human species, such as Neanderthals and Denisovans, in the genomes of modern humans. By analyzing high-coverage genome sequencing data, NUMT detects that map to nuclear and mitochondrial DNA and classifies them based on their mtDNA source. This tool enables researchers to discover evidence of interbreeding between archaic and modern humans, providing new insights into the nature and extent of these ancient admixture events.

Topic

Sequencing;Workflows;DNA;Mapping;Phylogenetics

Detail

  • Operation: Splitting;Genotyping;Read mapping

  • Software interface: Command-line interface

  • Language: Python

  • License: Not stated

  • Cost: Free of charge

  • Version name: -

  • Credit: Max Planck Society, Estonian Research Council, European Union, Royal Society of New Zealand, German Alexander von Humboldt Foundation.

  • Input: -

  • Output: -

  • Contact: Robert Bücking robert_buecking@eva.mpg.de

  • Collection: -

  • Maturity: -

Publications

  • Archaic mitochondrial DNA inserts in modern day nuclear genomes.
  • Bücking R, et al. Archaic mitochondrial DNA inserts in modern day nuclear genomes. Archaic mitochondrial DNA inserts in modern day nuclear genomes. 2019; 20:1017. doi: 10.1186/s12864-019-6392-8
  • https://doi.org/10.1186/S12864-019-6392-8
  • PMID: 31878873
  • PMC: PMC6933719

Download and documentation

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