NanoPASS

"NanoPASS" (NanoParticle Administration Sedimentation Simulator) is a software tool designed to enhance the accuracy and reliability of nanotoxicological in vitro testing by providing an easy-to-use interface for dosimetric calculations. These calculations are crucial for determining the fraction of nanoparticles that come into contact with cells in a culture, considering the specific diffusion and sedimentation behavior of nanoparticles under various cell culture conditions.

Key Features of NanoPASS:

- User-Friendly Interface: NanoPASS is developed to lower the barrier to entry for researchers in nanotoxicology by providing an easy-to-use interface for the 3DSDD (3D Sedimentation, Diffusion, and Dosimetry) model. This feature is particularly beneficial for those without extensive bioinformatics knowledge.

- Enhanced Dosimetric Calculations: By integrating the physicochemical characteristics of nanoparticles and the specifics of the cell culture system, NanoPASS allows for precise dosimetric calculations, ensuring that researchers can accurately determine the amount of nanoparticles interacting with cells, essential for reliable experimental results.

- Improved Comparability and Interpretation: The tool ensures experimental comparability and correct interpretation of nanotoxicological results by providing standardized dosimetry calculations. This standardization is crucial for the field, where variability in nanoparticle behavior can significantly impact study outcomes.