NatalieQ

NatalieQ is a web server that is specifically designed to compute topology-based alignment of a specified query protein-protein interaction network to a selected target network using the Natalie algorithm. The server is a valuable tool that enables researchers to take into account molecular interactions, which are crucial to adequately model the complex behavior of biological systems.
The tool incorporates similarity at both the sequence and the network level to compute alignments that allow for the transfer of functional annotation as well as for the prediction of missing interactions. By using topology-based network alignment, NatalieQ is able to produce results complementary to those obtained by using sequence similarity alone, demonstrating its ability to predict putative interactions.
NatalieQ includes a biological case study involving the Wnt signaling pathway, which is used to illustrate the capabilities of the server. The Wnt signaling pathway is an important pathway in developmental biology that plays a critical role in cell proliferation, cell polarity, and cell fate determination.