NgsRelate

The software tool NgsRelate is a tool for estimating pairwise relatedness from next-generation sequencing (NGS) data. It provides maximum likelihood estimates based on genotype likelihoods, taking into account the inherent uncertainty of the genotypes, which is important for NGS data of low depth. The tool has been shown to provide markedly better estimates for low-depth NGS data than existing genotype-based methods, using both simulated and real data.

Topic

DNA;Sequencing;Genotype and phenotype;Statistics and probability

Detail

  • Operation: Sequence comparison

  • Software interface: Command-line user interface

  • Language: C++

  • License: GNU General Public License v2.0

  • Cost: Free

  • Version name: v2.0

  • Credit: The Danish National Research Foundation, the Danish Council for Independent Research.

  • Input: -

  • Output: -

  • Contact: ida@binf.ku.dk

  • Collection: -

  • Maturity: Stable

Publications

  • NgsRelate: a software tool for estimating pairwise relatedness from next-generation sequencing data.
  • Korneliussen TS and Moltke I. NgsRelate: a software tool for estimating pairwise relatedness from next-generation sequencing data. NgsRelate: a software tool for estimating pairwise relatedness from next-generation sequencing data. 2015; 31:4009-11. doi: 10.1093/bioinformatics/btv509
  • https://doi.org/10.1093/bioinformatics/btv509
  • PMID: 26323718
  • PMC: PMC4673978

Download and documentation

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