OLGA

OLGA (Optimized Likelihood estimate of immunoGlobulin Amino-acid sequences) software package computes the generation probability of a given CDR3 amino acid sequence motif. The OLGA algorithm uses Dynamic Programming (DP) and can compute probabilities V(D)J recombination in B or T cells given V/J restriction or without it.

Topic

Immunology;Sequence analysis;Applied mathematics

Detail

  • Operation: Sequence analysis

  • Software interface: Command-line user interface

  • Language: Python

  • License: GNU General Public License v3

  • Cost: Free

  • Version name: 1.2.4

  • Credit: European Research Council, NSF, V Foundation.

  • Input: -

  • Output: -

  • Contact: Aleksandra M Walczak awalczak@lpt.ens.fr, Thierry Mora tmora@lps.ens.fr

  • Collection: -

  • Maturity: -

Publications

  • OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs
  • Sethna Z, Elhanati Y, Callan CG, Walczak AM, Mora T. OLGA: fast computation of generation probabilities of B- and T-cell receptor amino acid sequences and motifs. Bioinformatics. 2019 Sep 1;35(17):2974-2981. doi: 10.1093/bioinformatics/btz035. PMID: 30657870; PMCID: PMC6735909.
  • https://doi.org/10.1093/bioinformatics/btz035
  • PMID: 30657870
  • PMC: PMC6735909

Download and documentation

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