PAFway
PAFway is a novel software tool that simplifies the interpretation of large and complex gene networks by estimating pairwise associations between functional annotations within biological networks and pathways. Its primary objective is to address whether genes with a specific function tend to regulate genes with another particular function, thus shedding light on the intricate regulatory relationships within biological systems.
The tool facilitates the visualization of these relationships through heatmaps or networks, mapping out the connections between different biological functions in a visually accessible manner. This feature is particularly useful for researchers looking to understand the functional interplay within gene networks and pathways, enabling a more profound comprehension of biological processes.
Topic
Molecular interactions, pathways and networks;Plant biology;Bioinformatics;Biotechnology;Systems biology
Detail
Operation: Network visualisation;Gene functional annotation;Gene regulatory network prediction
Software interface: Library
Language: R
License: GNU General Public License >= version 2
Cost: Free with restrictions
Version name: 0.1.2
Credit: Engineering and Physical Sciences Research Council (EPSRC), Biotechnology and Biological Sciences Research Council (BBSRC), United Kingdom Research and Innovation (UKRI).
Input: -
Output: -
Contact: Daphne Ezer daphne.ezer@york.ac.uk
Collection: -
Maturity: -
Publications
- PAFway: pairwise associations between functional annotations in biological networks and pathways.
- Mahjoub M and Ezer D. PAFway: pairwise associations between functional annotations in biological networks and pathways. PAFway: pairwise associations between functional annotations in biological networks and pathways. 2020; 36:4963-4964. doi: 10.1093/bioinformatics/btaa639
- https://doi.org/10.1093/BIOINFORMATICS/BTAA639
- PMID: 32678900
- PMC: PMC7750965
Download and documentation
Source: https://github.com/ezer/PAFway
Documentation: https://github.com/ezer/PAFway/tree/master/man
Home page: https://github.com/ezer/PAFway
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