PCAN

The software tool "PCAN" (Phenotype Consensus Analysis) addresses the challenge of bridging genotype and phenotype in biomedical research by integrating known gene-phenotype associations within molecular signaling networks. PCAN assesses the consensus semantic similarity of phenotypes in a candidate gene's signaling neighborhood, offering an intuitive approach to prioritize and interpret genes underlying disease traits. The method demonstrates significant phenotype consensus for a substantial portion of OMIM disease-gene associations, showcasing its effectiveness. The tool is designed to be flexible and versatile, allowing for easy configuration and extension.