PLAAC

The PLAAC software tool is a web application that scans protein sequences for domains with prion-like amino acid composition. It is designed to identify prion-forming domains in proteins with biased amino acid composition, particularly enriched for Q or N. Users can upload sequence files or paste sequences directly into a textbox, and PLAAC ranks the input sequences by several summary scores, allowing scores along sequences to be visualized.

Topic

Machine learning;Protein sites, features and motifs

Detail

  • Operation: Protein sequence analysis

  • Software interface: Web user interface

  • Language: R;Java

  • License: MIT License

  • Cost: Free

  • Version name: -

  • Credit: The G. Harold and Leila Y. Mathers Foundation, Howard Hughes Medical Institute, the National Institutes of Health (NIH).

  • Input: -

  • Output: -

  • Contact: lindquist_admin@wi.mit.edu, oliver.king@umassmed.edu

  • Collection: -

  • Maturity: -

Publications

  • PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition.
  • Lancaster AK, et al. PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition. PLAAC: a web and command-line application to identify proteins with prion-like amino acid composition. 2014; 30:2501-2. doi: 10.1093/bioinformatics/btu310
  • https://doi.org/10.1093/bioinformatics/btu310
  • PMID: 24825614
  • PMC: PMC4147883

Download and documentation

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