PRODIGY

PRODIGY is a web server that can predict the binding affinity of protein-protein complexes from their 3D structure. It uses a simple yet highly effective predictive model based on intermolecular contacts and properties derived from non-interface surface. This tool is designed to provide valuable insights into the structural determinants of protein-protein interactions, which in turn can help researchers understand biological functions, diseases, and develop new therapeutics. The PRODIGY server is freely available online at http://milou.science.uu.nl/services/PRODIGY, and users can contact the developers at [a.m.j.j.bonvin@uu.nl](mailto:a.m.j.j.bonvin@uu.nl) or [a.vangone@uu.nl](mailto:a.vangone@uu.nl) for any questions or feedback.

Topic

Molecular modelling;Protein interactions;Molecular interactions, pathways and networks

Detail

  • Operation: Prediction and recognition

  • Software interface: Web application

  • Language: -

  • License: Apache License, Version 2.0

  • Cost: Free with restrictions

  • Version name: -

  • Credit: -

  • Input: -

  • Output: -

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  • Collection: -

  • Maturity: Mature

Publications

  • PRODIGY: a web server for predicting the binding affinity of protein-protein complexes.
  • Xue LC, et al. PRODIGY: a web server for predicting the binding affinity of protein-protein complexes. Bioinformatics 2016; 32:3676-3678. doi: 10.1093/bioinformatics/btw514
  • https://doi.org/10.1093/bioinformatics/btw514
  • PMID: -
  • PMC: -

Download and documentation

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