PeakLink

PeakLink (PL) is a method for accurately linking peptide peaks between two LC-MS/MS runs. PL utilizes the time and frequency domain in a non-linear support vector machine (SVM) classifier to identify corresponding peptide peaks and reduce noise through wavelet transformation. This method improves existing methods based on similarities in retention time (rt), mass, or peak shape. It has the potential to enable large-scale proteomics studies to be conducted effectively.

Topic

Proteomics experiment;Small molecules;Data mining

Detail

  • Operation: Peak detection

  • Software interface: Command-line user interface

  • Language: MATLAB

  • License: -

  • Cost: Free

  • Version name: -

  • Credit: The National Institute on Minority Health and Health Disparities from the National Institutes of Health (NIH).

  • Input: -

  • Output: -

  • Contact: Mehrab Ghanat Bari m.ghanatbari@gmail.com

  • Collection: -

  • Maturity: -

Publications

  • PeakLink: a new peptide peak linking method in LC-MS/MS using wavelet and SVM.
  • Ghanat Bari M, et al. PeakLink: a new peptide peak linking method in LC-MS/MS using wavelet and SVM. PeakLink: a new peptide peak linking method in LC-MS/MS using wavelet and SVM. 2014; 30:2464-70. doi: 10.1093/bioinformatics/btu299
  • https://doi.org/10.1093/bioinformatics/btu299
  • PMID: 24813213
  • PMC: PMC4147882

Download and documentation

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