RAREMETAL

RAREMETAL is a software tool for the meta-analysis of rare variants using genotyped data from arrays or sequencing. The RAREMETAL algorithm includes functions for individual studies accounting for study-specific covariates, family and population structure, single variant, and burden tests, and conditional association analyses. This tool can also produce summaries of linkage disequilibrium information.

Topic

Genetics;Sequencing;DNA polymorphism

Detail

  • Operation: Genetic variation analysis

  • Software interface: Command-line user interface

  • Language: Shell;C++;Fortran;C

  • License: -

  • Cost: Free

  • Version name: 4.15.1

  • Credit: National Human Genome Research Institute, National Heart, Lung, and Blood Institute.

  • Input: summary statistics and covariance matrices of score statistics generated by RAREMETALWORKER or rvtests

  • Output: -

  • Contact: Gonçalo R. Abecasis goncalo@umich.edu, Shuang Feng sfengsph@umich.edu

  • Collection: -

  • Maturity: Mature

Publications

  • RAREMETAL: fast and powerful meta-analysis for rare variants.
  • Feng S, Liu D, Zhan X, Wing MK, Abecasis GR. RAREMETAL: fast and powerful meta-analysis for rare variants. Bioinformatics. 2014 Oct;30(19):2828-9. doi: 10.1093/bioinformatics/btu367. Epub 2014 Jun 3. PMID: 24894501; PMCID: PMC4173011.
  • https://doi.org/10.1093/bioinformatics/btu367
  • PMID: 24894501
  • PMC: PMC4173011

Download and documentation

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