RTopper

"RTopper" is a novel data analysis tool designed to interpret simultaneous measurements of multiple genomic features obtained from the same biological samples. Recognizing the challenge posed by the diversity of genomic information, RTopper utilizes gene sets as a unifying framework to provide a standard scale that facilitates the interpretation of various types of genomic data. This approach allows for detecting genetic effects that may manifest through different mechanisms across different samples.

A significant advantage of RTopper is its ability to identify and validate disease-related gene sets that might remain undiscovered by analyzing individual data types alone. By integrating multiple data types, RTopper enhances researchers' ability to uncover complex genetic influences on diseases, offering new insights into their underlying biological mechanisms.