SWISS-MODEL Workspace

SWISS-MODEL Workspace is an advanced and powerful software tool designed to facilitate the homology modeling of proteins. Homology models of proteins are of great interest for planning and analyzing biological experiments when no experimental three-dimensional structures are available. Building homology models requires specialized programs and up-to-date sequence and structural databases. However, integrating all required tools, programs, and databases into a single web-based workspace simplifies access to homology modeling from a computer with a web connection without the need to download and install large program packages and databases.

SWISS-MODEL Workspace is a user-friendly and easy-to-use software tool that provides a personal working environment for each user where multiple modeling projects can be carried out simultaneously. The workspace is integrated with all the necessary protein sequence and structure databases, which are accessible from the workspace and updated at regular intervals. This ensures the user can access the latest and most up-to-date sequence and structural information. The workspace also includes tools for template selection, model building, and structure quality evaluation that can be invoked from within the workspace, making the modeling process more efficient and accurate.

One of the key advantages of SWISS-MODEL Workspace is its ability to assist and guide the user in building protein homology models at different levels of complexity. The software tool is designed to cater to the needs of both novice and advanced users, making it a versatile and flexible solution for protein structure homology modeling. The workflow and usage of the workspace are also illustrated by modeling human Cyclin A1 and human Transmembrane Protease 3, making it easier for users to understand and apply the software tool in their research.