SigUNet

SigUNet is a software tool for signal peptide recognition using deep learning techniques, specifically convolutional neural networks (CNNs). The key points about SigUNet are:

1. It employs a CNN architecture without fully connected layers, an advanced network design borrowed from computer vision applications.

2. The proposed CNN is more complex than the one-hidden-layer neural networks or hidden Markov models used in existing signal peptide predictors.

3. SigUNet performs better on eukaryotic data than current signal peptide predictors.

4. The study also shows that model reduction and data augmentation techniques help SigUNet effectively predict bacterial data.

5. The development of SigUNet makes three main contributions:
a) Providing an accurate signal peptide recognizer
b) Demonstrating the potential of leveraging advanced networks from other fields for signal peptide recognition
c) Proposing important modifications while adopting complex networks for this specific task

Topic

Small molecules;Protein sites, features and motifs;Protein targeting and localisation;Machine learning;Model organisms

Detail

  • Operation: Protein signal peptide detection;Pathway or network comparison;Pathway or network prediction

  • Software interface: Command-line user interface

  • Language: Python

  • License: Not stated

  • Cost: Free of charge

  • Version name: -

  • Credit: Ministry of Science and Technology, Taiwan.

  • Input: -

  • Output: -

  • Contact: Darby Tien-Hao Chang darby@mail.ncku.edu.tw

  • Collection: -

  • Maturity: -

Publications

  • SigUNet: signal peptide recognition based on semantic segmentation.
  • Wu JM, et al. SigUNet: signal peptide recognition based on semantic segmentation. SigUNet: signal peptide recognition based on semantic segmentation. 2019; 20:677. doi: 10.1186/s12859-019-3245-z
  • https://doi.org/10.1186/S12859-019-3245-Z
  • PMID: 31861981
  • PMC: PMC6923836

Download and documentation


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