SimSpliceEvol

SimSpliceEvol is a Python-based software tool that simulates the evolution of alternative transcripts along a given gene tree. Unlike existing sequence evolution simulation methods, SimSpliceEvol incorporates alternative splicing events, gene exon-intron structure evolution, and traditional sequence evolution events, allowing researchers to generate simulated data that can be used to evaluate the performance and accuracy of various spliced RNA sequence analysis methods, such as spliced alignment, multiple cDNA alignment, orthologous exon identification, splicing orthology inference, and transcript phylogeny inference.