SomaticSignatures

The SomaticSignatures R package is part of the Bioconductor project to identify mutational signatures from cancer sequencing data. These signatures represent patterns in the occurrence of somatic single-nucleotide variants, shedding light on the underlying mutational processes driving cancer development. The package stands out for its flexibility, interoperability, and ease of use, enabling researchers to perform large-scale, cross-dataset estimation of mutational signatures. It incorporates existing methods for pattern decomposition and allows for customization through user-defined approaches.