Sprites

The software tool "Sprites" aims to detect deletions, an important type of structural variations associated with genetic diseases, from sequencing data. It aligns a whole soft-clipping read to a target sequence to find the longest prefix or suffix of the read that has a match in the target sequence, in order to detect deletions with microhomologies and microinsertions. Sprites outperforms other current methods in detecting deletions in both simulated and real data in terms of F-score.