TZMD

TZMD (Tetranucleotide-derived Z-value Manhattan Distance) is a genomic composition-based method for differentiating bacterial species and strains with high resolution. It improves existing methods like TETRA (tetranucleotide-derived z-value Pearson correlation coefficient) by differentiating closely related organisms, including intra-genus species, subspecies, and intraspecific strains. TZMD reflects the maximal genome difference and can determine clonal strains using the TZMD = 0 criteria, encompassing identical composition, high average nucleotide identity, and a high percentage of shared genomes.

Topic

Taxonomy;Metagenomics;Model organisms;DNA polymorphism;Phylogeny

Detail

  • Operation: Standardisation and normalisation;Genotyping;Query and retrieval

  • Software interface: Command-line user interface

  • Language: Perl

  • License: Not stated

  • Cost: Free of charge

  • Version name: -

  • Credit: Guangxi Research Foundation for Science &Technology Base and Talent Special, Natural Science Foundation of Guangxi, Lijiang Scholar Award in Guilin, High Level of Innovation Team and Outstanding Scholars Program in Colleges and Universities in Guangxi, Hundred Talents Program “the Introduction of Overseas High-Level Talents in Colleges and Universities in Guangxi.”

  • Input: -

  • Output: -

  • Contact: Yizhuang Zhou zhouyizhuang3@163.com ,Junfei Jin changliangzijin@163.com

  • Collection: -

  • Maturity: -

Publications

  • A high-resolution genomic composition-based method with the ability to distinguish similar bacterial organisms.
  • Zhou Y, et al. A high-resolution genomic composition-based method with the ability to distinguish similar bacterial organisms. A high-resolution genomic composition-based method with the ability to distinguish similar bacterial organisms. 2019; 20:754. doi: 10.1186/s12864-019-6119-x
  • https://doi.org/10.1186/S12864-019-6119-X
  • PMID: 31638897
  • PMC: PMC6805505

Download and documentation

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