UniNovo

UniNovo is a universal de novo sequencing algorithm designed to analyze all types of tandem mass spectra. UniNovo uses an improved scoring function that captures the dependencies between different ion types, which are learned automatically using a modified offset frequency function. UniNovo's performance was compared to other de novo sequencing tools using various types of spectra and was found to be superior for ETD spectra and comparable to others for CID and HCD spectra. UniNovo estimates the probability that each reported reconstruction is correct, using simple statistics that are accurate for all tested types of spectra.

Topic

Proteomics

Detail

  • Operation: Peptide identification

  • Software interface: Graphical user interface

  • Language: Java

  • License: Not stated

  • Cost: Free

  • Version name: -

  • Credit: The National Center for Research Resources of NIH.

  • Input: -

  • Output: -

  • Contact: Kyowon Jeong k1jeong@ucsd.edu, kwj@ucsd.edu

  • Collection: -

  • Maturity: -

Publications

  • UniNovo: a universal tool for de novo peptide sequencing.
  • Jeong K, et al. UniNovo: a universal tool for de novo peptide sequencing. UniNovo: a universal tool for de novo peptide sequencing. 2013; 29:1953-62. doi: 10.1093/bioinformatics/btt338
  • https://doi.org/10.1093/bioinformatics/btt338
  • PMID: 23766417
  • PMC: PMC3722526

Download and documentation

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