VIC

VIC classifies somatic sequence variants in cancer according to the 2017 AMP, ASCO, and CAP guidelines to support standardized interpretation of clinical significance.

Key Features:

• Guideline-Based Variant Classification: Interprets somatic variants using the four-tier classification framework defined by the Association for Molecular Pathology (AMP), American Society of Clinical Oncology (ASCO), and College of American Pathologists (CAP).
• Automated Evidence-Based Interpretation: Processes pre-annotated variant files to automatically evaluate evidence criteria used in somatic variant classification.
• Integration of External Databases and Predictive Tools: Incorporates information from publicly available databases and predictive software programs to support variant interpretation.
• Customizable Evidence Incorporation: Allows additional evidence to be integrated to refine classification of clinical significance.

Scientific Applications:

• Cancer Variant Interpretation: Classifies somatic sequence variants identified in cancer sequencing datasets.
• Clinical Genomics Analysis: Supports interpretation of clinically relevant cancer variants in diagnostic sequencing panels.
• Precision Oncology Research: Facilitates systematic evaluation of genetic variants associated with cancer pathogenesis and treatment response.

Methodology:

VIC analyzes pre-annotated somatic variant files, evaluates evidence criteria defined in the AMP, ASCO, and CAP 2017 guidelines using information from public databases and predictive software, and assigns variants to a four-tier clinical significance classification.