Xtalk

Xtalk is a path-based approach to identifying crosstalk between signaling pathways. By computing the average length of multiple short paths connecting receptors in one pathway to transcription factors in another, it offers a more precise way to find the interactions and mechanisms that support crosstalk.

Topic

Transcription factors and regulatory sites;Molecular interactions, pathways and networks;Sequence analysis

Detail

  • Operation: Pathway or network prediction

  • Software interface: Web user interface

  • Language: -

  • License: -

  • Cost: Free

  • Version name: 1.0

  • Credit: Environmental Protection Agency grant, National Science Foundation, National Institute of General Medical Sciences of the National Institutes of Health grant, National Research Service Award.

  • Input: -

  • Output: -

  • Contact: Allison N Tegge ategge@vt.edu, T M Murali murali@cs.vt.edu

  • Collection: -

  • Maturity: -

Publications

  • Xtalk: a path-based approach for identifying crosstalk between signaling pathways.
  • Tegge AN, et al. Xtalk: a path-based approach for identifying crosstalk between signaling pathways. Xtalk: a path-based approach for identifying crosstalk between signaling pathways. 2016; 32:242-51. doi: 10.1093/bioinformatics/btv549
  • https://doi.org/10.1093/BIOINFORMATICS/BTV549
  • PMID: 26400040
  • PMC: PMC4907392

Download and documentation

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