cSupB

cSupB, standing for colored superbubble, is a method for navigating and elucidating the structural complexity of genome graphs, facilitating the representation and analysis of pan-genomic data. As sequencing and assembly technologies advance, producing high-quality chromosome-level and haplotype-resolved genomic sequences, the need for efficient computational pan-genomics tools has become increasingly critical. Genome graphs represent a powerful model for depicting pangenomes, but their intricate structures pose significant challenges for presenting genome information intuitively akin to linear reference genomes.

Addressing this, cSupB simplifies the complexity of genome graphs by organizing species- or population-specific haplotype sequences of interest. It introduces a tri-tuple coordinate system that integrates an offset value, topological structure, and sample information, providing a comprehensive framework for analyzing genome graph spatial structures and their corresponding data.