cordial

The Functional Pathway Inference Analysis (FPIA) method, implemented in the 'cordial' R package, is a novel strategy for inferring biochemical pathways by identifying genes with correlated anti-proliferative effects across multiple cell lines. The underlying hypothesis is that genes influencing cell viability in a similar manner across various contexts likely participate in the same pathway. This approach leverages recent large-scale RNAi screens to systematically identify such correlated gene dependencies.

Topic

Molecular interactions, pathways and networks;Oncology;Small molecules;Endocrinology and metabolism;Gene expression

Detail

  • Operation: Enrichment analysis;Expression correlation analysis;Pathway analysis;Weighted correlation network analysis

  • Software interface: Library

  • Language: R

  • License: The MIT License + file LICENSE

  • Cost: Free

  • Version name: v0.01.09

  • Credit: Blood Cancer UK, Medical Research Council, Cancer Research UK.

  • Input: -

  • Output: -

  • Contact: Pedro R Cutillas p.cutillas@qmul.ac.uk

  • Collection: -

  • Maturity: -

Publications

  • Systematic identification of biochemical networks in cancer cells by functional pathway inference analysis.
  • Badshah II and Cutillas PR. Systematic identification of biochemical networks in cancer cells by functional pathway inference analysis. Systematic identification of biochemical networks in cancer cells by functional pathway inference analysis. 2023; 39:(unknown pages). doi: 10.1093/bioinformatics/btac769
  • https://doi.org/10.1093/BIOINFORMATICS/BTAC769
  • PMID: 36448701
  • PMC: PMC9805595

Download and documentation

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