deconstructSigs

deconstructSigs is an R software package for specifying contributions of each known mutational process in a single tumor sample to define a mutational profile and evolutionary patterns. The deconstructSigs includes functions to compute weighted contributions for each mutation signature and plot the profiles.

Topic

Oncology;Genetic variation;Evolutionary biology;DNA

Detail

  • Operation: Pathway or network prediction

  • Software interface: Library

  • Language: R

  • License: GNU General Public License v2 | v3

  • Cost: Free

  • Version name: 1.8.0

  • Credit: Cancer Research UK (TRACERx), the CRUK Lung Cancer Centre of Excellence, Stand Up 2 Cancer (SU2C), the Rosetrees Trust, NovoNordisk Foundation (ID 16584), EU FP7, the Prostate Cancer Foundation, the Breast Cancer Research Foundation, the European Research Council (THESEUS), National Institute for Health Research University College London Hospitals Biomedical Research Centre, UCL Cancer Institute Research Trust.

  • Input: -

  • Output: -

  • Contact: Rachel Rosenthal rachel.rosenthal.14@ucl.ac.uk. Javier Herrero javier.herrero@ucl.ac.uk

  • Collection: -

  • Maturity: Mature

Publications

  • DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution.
  • Rosenthal R, McGranahan N, Herrero J, Taylor BS, Swanton C. DeconstructSigs: delineating mutational processes in single tumors distinguishes DNA repair deficiencies and patterns of carcinoma evolution. Genome Biol. 2016 Feb 22;17:31. doi: 10.1186/s13059-016-0893-4. PMID: 26899170; PMCID: PMC4762164.
  • https://doi.org/10.1186/s13059-016-0893-4
  • PMID: 26899170
  • PMC: PMC4762164

Download and documentation

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