fcScan

fcScan is an R/ package designed to identify clusters of genomic sites based on user-defined criteria. This tool is handy for discovering cis-regulatory modules characterized by a specific combination of transcription factor binding sites within a defined window size. fcScan supports various input formats, including GRanges, data frames, and VCF/BED files, providing flexibility for different types of genomic data. It allows users to set criteria such as cluster size, inter-cluster distances, and the order and orientation of sites, making it adaptable to specific biological questions. With its ability to handle millions of sites efficiently, fcScan is suitable for analyzing high-throughput data generated by techniques like next-generation sequencing.

Topic

Transcription factors and regulatory sites;ChIP-seq;Genomics;Genetic variation

Detail

  • Operation: Clustering;Transcription factor binding site prediction;Variant calling

  • Software interface: Library

  • Language: R

  • License: Artistic License 2.0

  • Cost: Free

  • Version name: 1.16.0

  • Credit: Medical Practice Plan grant 320154 from the American University of Beirut (AUB), the National Council for Scientific Research.

  • Input: -

  • Output: -

  • Contact: Pierre Khoueiry pk17@aub.edu.lb Abdullah El-Kurdi ak161@aub.edu.lb

  • Collection: -

  • Maturity: Stable

Publications

  • fcScan: a versatile tool to cluster combinations of sites using genomic coordinates.
  • El-Kurdi A, et al. fcScan: a versatile tool to cluster combinations of sites using genomic coordinates. fcScan: a versatile tool to cluster combinations of sites using genomic coordinates. 2020; 21:194. doi: 10.1186/s12859-020-3536-4
  • https://doi.org/10.1186/S12859-020-3536-4
  • PMID: 32429868
  • PMC: PMC7236483

Download and documentation


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