geNetClassifier

geNetClassifier is a network-oriented, data-driven bioinformatics tool designed to enhance the analysis of transcriptomic studies by facilitating the robust identification and classification of gene markers across multiple disease subtypes. This R package, freely available on Bioconductor, aims to address the gap in integrative approaches for analyzing genome-wide expression data, whether from microarrays or RNA-Seq studies. It focuses on four key objectives: identifying gene sets associated with different pathological states when analyzed collectively, isolating a minimal subset of these genes that distinctly differentiates and classifies disease subtypes, quantifying the discriminative power of these genes, and elucidating the connections between genes characterizing each disease subtype.

Topic

Gene expression;Pathology

Detail

  • Operation: Sequence classification

  • Software interface: Command-line user interface,Library

  • Language: R

  • License: GNU General Public License, version 2

  • Cost: Free

  • Version name: 1.42.0

  • Credit: The "Junta de Castilla y Leon" (JCyL), the Spanish Ministry of Economy and Competitiveness (MINECO) through the National Institute of Health Carlos III (ISCiii), JCyL ("Ayudas a la Contratación de Personal Investigador") with the support of the European Social Fund (ESF), Celgene-CITRE with the grant Celegene-FICUS 2013.

  • Input: -

  • Output: -

  • Contact: Sara Aibar saibar@usal.es

  • Collection: -

  • Maturity: Stable

Publications

  • Analyse multiple disease subtypes and build associated gene networks using genome-wide expression profiles.
  • Aibar S, et al. Analyse multiple disease subtypes and build associated gene networks using genome-wide expression profiles. Analyse multiple disease subtypes and build associated gene networks using genome-wide expression profiles. 2015; 16 Suppl 5:S3. doi: 10.1186/1471-2164-16-S5-S3
  • https://doi.org/10.1186/1471-2164-16-S5-S3
  • PMID: 26040557
  • PMC: PMC4460584

Download and documentation


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