glmGamPoi

The software tool 'glmGamPoi' efficiently infers parameters of the Gamma-Poisson distribution for single-cell RNA-sequencing counts. It is designed to overcome challenges associated with large single-cell datasets, providing a faster and more accurate alternative to existing methods. The tool is particularly useful for tasks like differential expression analysis and principal component analysis. Notably, 'glmGamPoi' can handle data on disk without requiring simultaneous loading into RAM.

Topic

RNA-Seq;Cell biology;Gene expression

Detail

  • Operation: Essential dynamics;Regression analysis;Dimensionality reduction

  • Software interface: Library

  • Language: R,C++

  • License: The GNU General Public License v3.0

  • Cost: Free

  • Version name: 1.14.0

  • Credit: The EMBL International PhD Programme, the European Research Council Synergy Grant.

  • Input: -

  • Output: -

  • Contact: Constantin Ahlmann-Eltze constantin.ahlmann@embl.de

  • Collection: -

  • Maturity: Stable

Publications

  • glmGamPoi: fitting Gamma-Poisson generalized linear models on single cell count data.
  • Ahlmann-Eltze C and Huber W. glmGamPoi: fitting Gamma-Poisson generalized linear models on single cell count data. glmGamPoi: fitting Gamma-Poisson generalized linear models on single cell count data. 2021; 36:5701-5702. doi: 10.1093/bioinformatics/btaa1009
  • https://doi.org/10.1093/BIOINFORMATICS/BTAA1009
  • PMID: 33295604
  • PMC: PMC8023675

Download and documentation

< Back to DB search