km2gcn

km2gcn is an R package that enhances the widely used Weighted Gene Co-expression Network Analysis (WGCNA) by incorporating k-means clustering as an additional processing step. This method improves the partitioning of gene co-expression networks (GCNs) into clusters of genes, known as modules. The authors demonstrate that applying k-means clustering after the conventional WGCNA process results in better network partitions, as evidenced by fewer misplaced genes, increased counts of replicable clusters across different tissues, improved enrichment of Gene Ontology terms, and more accurate partitions in simulated data.