mFASD

The software tool mFASD is a novel algorithm designed for discriminating between different types of metal-binding sites based on 3D structure data to improve the accuracy of metal-binding site prediction. The algorithm captures the characteristics of a metal-binding site by investigating the local chemical environment of a set of functional atoms in contact with the bound metal. A distance measure defined on functional atom sets enables the comparison between different metal-binding sites, achieving high sensitivity and accuracy.

Topic

Proteins;Protein binding sites;Protein structure analysis

Detail

  • Operation: Protein binding site prediction

  • Software interface: Command-line user interface

  • Language: Python

  • License: -

  • Cost: Free

  • Version name: -

  • Credit: The Ministry of Science and Technology, the National Natural Science Foundation of China.

  • Input: -

  • Output: -

  • Contact: liangzhi@ustc.edu.cn

  • Collection: -

  • Maturity: -

Publications

  • mFASD: a structure-based algorithm for discriminating different types of metal-binding sites.
  • He W, et al. mFASD: a structure-based algorithm for discriminating different types of metal-binding sites. mFASD: a structure-based algorithm for discriminating different types of metal-binding sites. 2015; 31:1938-44. doi: 10.1093/bioinformatics/btv044
  • https://doi.org/10.1093/bioinformatics/btv044
  • PMID: 25649619
  • PMC: -

Download and documentation

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