messina

"Messina" is a computational method designed to identify genes that exhibit aberrant expression patterns in only a subset of cancer cases. It addresses the diversity and complexity of morphologically similar cancers that may follow different clinical courses due to molecular heterogeneity. Traditional methods for analyzing expression profiling data may overlook such genes, potentially missing crucial molecular aberrations that define biologically relevant subtypes with significant implications for therapy.

The significance of Messina lies in its ability to complement existing methods by filling a critical gap in the analysis of global expression profiling data. It offers researchers a powerful tool to assist in identifying markers that define cancer subtypes.

Topic

Gene expression;Biomarkers;Biomedical science

Detail

  • Operation: Incident curve plotting;Differential gene expression analysis;Classification

  • Software interface: Command-line user interface,Library

  • Language: R

  • License: Eclipse Public License Version 1.0

  • Cost: Free

  • Version name: 1.38.0

  • Credit: The National Health and Medical Research Council of Australia, The Cancer Council NSW, the Cancer Institute NSW, the St Vincent's Clinic Foundation, the Royal Australasian College of Surgeons and the R. T. Hall Trust.

  • Input: Gene expression profile [Gene expression report format]

  • Output: Plot [Textual format] [Image format], Report [Textual format] [Image format]

  • Contact: Mark Pinese mpinese@ccia.org.au

  • Collection: -

  • Maturity: Stable

Publications

  • Messina: a novel analysis tool to identify biologically relevant molecules in disease.
  • Pinese M, et al. Messina: a novel analysis tool to identify biologically relevant molecules in disease. Messina: a novel analysis tool to identify biologically relevant molecules in disease. 2009; 4:e5337. doi: 10.1371/journal.pone.0005337
  • https://doi.org/10.1371/journal.pone.0005337
  • PMID: 19399185
  • PMC: PMC2671167

Download and documentation

< Back to DB search