miRLAB

miRLAB is an R package to streamline the process of inferring and validating miRNA-mRNA regulatory relationships, addressing the challenge of the time-consuming nature of current methodologies. It automates the workflow, from obtaining matched miRNA and mRNA expression profiles, typically from databases such as The Cancer Genome Atlas (TCGA), by applying computational methods for target prediction to validating them with literature and third-party databases. miRLAB includes pipelines for quickly testing new computational models, analyzing fresh datasets, and selecting appropriate methods to aid experimental design. The package encompasses a direct pipeline for accessing matched expression datasets from TCGA, incorporates 12 benchmark computational techniques for predicting miRNA-mRNA interactions, and offers functionalities for validating predictions with experimentally verified data and comparing outcomes from various computational approaches.