rDGIdb

rDGIdb is an R package that serves as an interface to the Drug-Gene Interaction Database (DGIdb). The package lets users identify potential drug targets based on aberrated genes or pathways discovered through next-generation sequencing (NGS) data analysis. By integrating information from 15 different sources, DGIdb provides a comprehensive resource for exploring drug-gene interactions.

The rDGIdb package enables R users to query the DGIdb easily and filter the results at various levels. This functionality is handy in medical data analysis pipelines, where associating genomic aberrations with phenotypic and clinical features is crucial. By incorporating the rDGIdb package into NGS pipelines, researchers can automate the identification of potential drug targets, streamline the interpretation of genomic data, and facilitate the development of personalized treatment strategies.

Topic

Drug discovery;Compound libraries and screening

Detail

  • Operation: Database search;Loading

  • Software interface: Command-line user interface, Library

  • Language: R

  • License: The MIT License

  • Cost: Free

  • Version name: 1.30.0

  • Credit: EU Horizon.

  • Input: -

  • Output: -

  • Contact: Lars Bosshard bosshard@nexus.ethz.ch

  • Collection: -

  • Maturity: Stable

Publications

  • Genomic variant annotation workflow for clinical applications
  • Thurnherr T, Singer F, Stekhoven DJ, Beerenwinkel N. Genomic variant annotation workflow for clinical applications. F1000Res. 2016 Aug 12;5:1963. doi: 10.12688/f1000research.9357.2. PMID: 27990260; PMCID: PMC5130070.
  • https://doi.org/10.12688/f1000research.9357.1
  • PMID: 27990260
  • PMC: PMC5130070

Download and documentation


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