shinyMethyl

shinyMethyl is a software package that facilitates the interactive quality control of DNA methylation data derived from Illumina 450k arrays. This tool efficiently summarizes experiments into compact R objects, the foundation for launching an interactive interface. Through reactive plots, shinyMethyl enables users to quickly and intuitively assess sample quality. It further supports the exploration of phenotypic associations via coloring and principal component analysis, enhancing the understanding of the data. The package simplifies the quality assessment process for large-scale methylation datasets, making it particularly useful for epigenome-wide association studies and analyzing data from resources like The Cancer Genome Atlas portal.

Topic

Methylated DNA immunoprecipitation;Epigenetics;Microarray experiment

Detail

  • Operation: Principal component plotting;Methylation analysis

  • Software interface: Command-line user interface,Library

  • Language: R

  • License: Artistic License 2.0

  • Cost: Free

  • Version name: 1.38.0

  • Credit: Natural Sciences and Engineering Research Council of Canada, les Fonds de recherche Nature et technologies du Québec, Johns Hopkins Head and Neck Cancer SPORE

  • Input: -

  • Output: -

  • Contact: Jean-Philippe Fortin fortin946@gmail.com

  • Collection: -

  • Maturity: Stable

Publications

  • shinyMethyl: interactive quality control of Illumina 450k DNA methylation arrays in R.
  • Fortin JP, et al. shinyMethyl: interactive quality control of Illumina 450k DNA methylation arrays in R. shinyMethyl: interactive quality control of Illumina 450k DNA methylation arrays in R. 2014; 3:175. doi: 10.12688/f1000research.4680.2
  • https://doi.org/10.12688/f1000research.4680.2
  • PMID: 25285208
  • PMC: PMC4176427

Download and documentation


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