tcR

The T cell receptors (TCRs) play a crucial role in adaptive immune response, and millions of unique TCRs are estimated to be present in each individual. The TCRmodel is an algorithm developed in the program Rosetta to model TCRs from sequence, and implemented as a web server to generate models quickly that users can investigate in the browser and download. The method was benchmarked using a set of nonredundant recently released TCR crystal structures, showing accurate and favorable results. The TCRmodel server provides an easy-to-use interface to enable the community to obtain insights into TCRs of interest and can be combined with methods to model and design TCR recognition of antigens.