Mining Symbionts of a SpiderTransmitted Fungus Illuminates Uncharted Biosynthetic Pathways to Cytotoxic Benzolactones

Spider sense: The fungus Rhizopus microsporus, isolated from necrotic tissue resulting from a spider bite, was found to contain bacteria (Burkholderia sp.) that produce a complex of highly cytotoxic compounds (necroximes). Analysis of the PKS/NRPS hybrid asse Read more at Wiley.com

Coronavirus SARS-CoV-2 infects cells of the intestine

Researchers from the Hubrecht Institute in Utrecht, Erasmus MC University Medical Center Rotterdam, and Maastricht University have found that the coronavirus SARS-CoV-2, which causes COVID-19, can infect the cells of the intestine and multiply there. Using st Read more at Eurekalert.org

neatbio added to PyPI

NeatBio - a simple Yet Another BioInformatics Library for DNA Sequence
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Medical, tech investments pay off in Covid-19 war - The Straits Times

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Genetic scientists map spread of Covid 19 coronavirus in New Zealand

By RNZ Genetic scientists mapping the spread of Covid-19 say that as few as 35 cases may have led to the outbreak here.ESR (Institute of Environmental Science and Research) has been analysing virus samples to try to build a... Read more at Nzherald.co.nz

Notice of a Joint Veterans Health Administration/National Cancer Institute Data Science Postdoctoral Fellowship - the Big Data Scientist Training Enhancement Program (BD-STEP)

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of a Joint Veterans Health Administration/National Cancer Institute Data Science Postdoctoral Fellowship - the Big Data Scientist Training Enhancement Program (BD-STEP) NO Read more at Nih.gov

AMP expresses support for citizen petition from the coalition to preserve access to pharmacogenomics

(Association for Molecular Pathology) AMP has submitted a formal response in support of the Citizen Petition from Hyman, Phelps & McNamara, P.C. on behalf of the Coalition to Preserve Access to Pharmacogenomics (PGx) Information. The response builds on AMP's Read more at Eurekalert.org

Professor warns COVID-19 data could inform surveillance system

PROFESSOR Anthony Bogues, Asa Messer Professor of Humanities and Critical Theory at Brown University, has warned that among the perils that could emerge after the COVID-19 pandemic is a surveillance system driven by data collected during the health crisis. Read more at Jamaicaobserver.com

Fighting coronavirus: European supercomputers join pharmaceutical companies in hunt for new drugs

Behind the Exscalate4CoV project stands an unprecedented consortium of the best scientific minds in the technological and bio-medical fields. Supported by 3 million of emergency EU funding, an increasing number of pharmaceutical companies and research instit Read more at Europa.eu

The SrrAB two-component system regulates Staphylococcus aureus pathogenicity through redox sensitive cysteines [Biophysics and Computational Biology]

Bacteria utilize sensory signal transduction systems to constantly survey and respond to changes in their environment. The human pathogen Staphylococcus aureus uses two-component signaling systems to sense its surroundings and adapt to hostile stresses of the Read more at Pnas.org

Insight into the protein solubility driving forces with neural attention

Author summary The solubility of proteins is a crucial biophysical aspect when it comes to understanding many human diseases and to improve the industrial processes for protein production. Due to its relevance, computational methods have been devised in order Read more at Plos.org

An in silico model of LINE-1-mediated neoplastic evolution

Abstract Motivation Recent research has uncovered roles for transposable elements (TEs) in multiple evolutionary processes, ranging from somatic evolution in cancer to putatively adaptive germline evolution across species. Most models of TE population dynam Read more at Oup.com

scDoc: correcting drop-out events in single-cell RNA-seq data

Abstract Motivation Single-cell RNA sequencing (scRNA-seq) has become an important tool to unravel cellular heterogeneity, discover new cell (sub)types, and understand cell development at single-cell resolution. However, one major challenge to scRNA-seq res Read more at Oup.com

CiteFuse enables multi-modal analysis of CITE-seq data

Abstract Motivation Multi-modal profiling of single cells represents one of the latest technological advancements in molecular biology. Among various single-cell multi-modal strategies, cellular indexing of transcriptomes and epitopes by sequencing (CITE-se Read more at Oup.com

An Out-of-Patagonia migration explains the worldwide diversity and distribution of Saccharomyces eubayanus lineages

Author summary Lager yeast history has intrigued scientists for decades. The recent isolation of S. eubayanus, the lager yeast ancestor, represents an unprecedented opportunity to extend our knowledge on yeast phylogeography and the origins of the S. pastoria Read more at Plos.org

Accidentally deleted python 3.5 from Ubuntu 16.04 - all my files went and I cannot reinstall python package

I apologise for any technical incorrectness, I am a complete beginner in bioinformatics with really limited linux knowledge. I have the following problem accidentally deleted python3.5 from my vm Ubuntu 16.04. Upon doing that, all my files went with it and Read more at Askubuntu.com

Optimization of Co-evolution Analysis through Phylogenetic Profiling Reveals Pathway-Specific Signals

Abstract Summary The exponential growth in available genomic data is expected to reach full sequencing of a million genomes in the coming decade. Improving and developing methods to analyze these genomes and to reveal their utility is of major interest in a Read more at Oup.com

Simultaneous SNP selection and adjustment for population structure in high dimensional prediction models

Author summary This work addresses a recurring challenge in the analysis and interpretation of genetic association studies: which genetic variants can best predict and are independently associated with a given phenotype in the presence of population structure Read more at Plos.org

Discovery of bacterial enzyme activity could lead to new sugar-based drugs

Researchers from DTU Biosustain and DTU Bioengineering have elucidated the activity of the enzyme N-acetylgalactosaminidase (GH109) whose mechanism of activity has until now been a mystery. This enzyme can convert a group of low cost, abundant so-called beta- Read more at Phys.org

zga added to PyPI

Prokaryotic genome assembly and annotation pipeline
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