Africa: A Viral Hit? The Sequence of Coronavirus Makes Surprisingly Lovely Music

[The Conversation Africa] All my life I've been involved in music and molecular biology. At the crossroads between science and art, I see great scope for insight. Read more at AllAfrica - Top Africa News

Global Whole Genome And Exome Sequencing Market 2020-2023:New Consumers, New Technologies, New Specializations

DUBLIN, Oct. 19, 2020 /PRNewswire/ -- The "Whole Genome And Exome Sequencing Markets - By Research, Clinical, Direct to Consumer, AgriBio & Tumor with Executive and Consultant Guides 2020 to 2024" report has been added to ResearchAndMarkets.com's offering. Th Read more at PRNewswire

Uncovering ecological state dynamics with hidden Markov models

By formally disentangling state and observation processes based on simple yet powerful mathematical properties that can be used to describe many ecological phenomena, hidden Markov models (HMMs) can facilitate inferences about complex system state dynamics th Read more at Wiley.com

The Ccr4-Not complex regulates TORC1 signaling and mitochondrial metabolism by promoting vacuole V-ATPase activity

Author summary Eukaryotic cells dynamically control nutrient signaling pathways to regulate metabolism, anabolic growth, and cell proliferation through molecular effectors that remain poorly understood. The Ccr4-Not complex is a multiprotein regulatory factor Read more at Plos.org

Lessons must go on

NOT all knowledge can be learnt through lectures and discussions. Read full story
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The NS1 protein of the parvovirus MVM Aids in the localization of the viral genome to cellular sites of DNA damage

Author summary Parvoviruses are among the simplest of viruses, depending almost exclusively on host cell factors to successfully replicate. We have previously shown that the parvovirus Minute Virus of Mice (MVM) establishes replication centers at sites that a Read more at Plos.org

Notre Dame adopts saliva-based testing as part of its surveillance testing strategy

From the beginning of the COVID-19 pandemic, medical experts have been looking for inexpensive and effective ways to detect positive cases. While nasal swab and nasopharyngeal testing gained traction across the U.S., saliva-based testing is becoming more prom Read more at Ndsmcobserver.com

Quorum sensing N-Acyl homoserine lactones are a new class of anti-schistosomal

Author summary Schistosomiasis, caused by infection with blood fluke schistosomes, is a neglected tropical disease that negatively impacts the lives of approximately 300 million people worldwide. In the absence of a vaccine, it is currently controlled by a si Read more at Plos.org

Weekly dengue forecasts in Iquitos, Peru; San Juan, Puerto Rico; and Singapore

Author summary Accurate and timely forecasts of dengue fever can help mitigate the impact of the disease. Currently, regression and time series models are frequently used to predict dengue cases and outbreaks. However, these models may be limited in terms of Read more at Plos.org

BinaryCIF and CIFToolsLightweight, efficient and extensible macromolecular data management

3D macromolecular structural data is growing ever more complex and plentiful in the wake of substantive advances in experimental and computational structure determination methods including macromolecular crystallography, cryo-electron microscopy, and integrat Read more at Plos.org

In silico characterisation of stand-alone response regulators of Streptococcus pyogenes

Bacterial stand-alone response regulators (RRs) are pivotal to the control of gene transcription in response to changing cytosolic and extracellular microenvironments during infection. The genome of group A Streptococcus (GAS) encodes more than 30 stand-alo Read more at Plos.org

Predicting antimicrobial resistance using conserved genes

Author summary Machine learning models for predicting AMR phenotypes from sequence data are often built using features derived from well-studied sets of AMR genes, or from whole genome sequences. In this study, we build models using core genes that are held i Read more at Plos.org