Correlations from structure and phylogeny combine constructively in the inference of protein partners from sequences

Author summary In protein sequence data, the amino acid usages at different sites of a protein or of two interacting proteins can be correlated because of functional constraints. For instance, the need to maintain physico-chemical complementarity among two si Read more at Plos.org

The structural context of posttranslational modifications at a proteome-wide scale

A combination of the comprehensive structural predictions of AlphaFold2 and large-scale proteomics data on post-translational modifications (PTMs) reveals novel insights into the functional importance of PTMs, based on their structural context. Read more at Plos.org

Machine learning sequence prioritization for cell type-specific enhancer design

Recent discoveries of extreme cellular diversity in the brain warrant rapid development of technologies to access specific cell populations within heterogeneous tissue. Available approaches for engineering-targeted technologies for new neuron subtypes are low Read more at Elifesciences.org

An evolutionary conserved detoxification system for membrane lipidderived peroxyl radicals in Gram-negative bacteria

How do double-membraned Gram-negative bacteria overcome lipid peroxidation stress? This study shows that a periplasmic lipocalin, a membrane cytochrome b561, and a cytoplasmic aldehyde reductase are components of a novel evolutionarily conserved peroxidation Read more at Plos.org

Annotating functional effects of non-coding variants in neuropsychiatric cell types by deep transfer learning

Author summary A large number of genetic variants have been statistically associated with the risks of common diseases. However, whether such variants are actual risk variants and when and where they function are often unknown. To address this challenge, mach Read more at Plos.org

TFAP2 paralogs facilitate chromatin access for MITF at pigmentation and cell proliferation genes

Author summary Differentiation of melanocytes, the pigment producing cells in your skin, is controlled by a gene regulatory network governed by the master regulator protein, MITF. Remarkably, the level of MITF activity also determines the invasive, proliferat Read more at Plos.org

GitHub - auctors/free-lunch: A curated list of free Windows software, online services and resources.

A curated list of free Windows software, online services and resources. - GitHub - auctors/free-lunch: A curated list of free Windows software, online services and resources. Read more at Github.com

Drug-discovery pioneer Verseon delivers breakthrough once predicted by Steve Jobs

LONDON, May 16, 2022 /PRNewswire/ -- Apple's visionary founder Steve Jobs once said, "The biggest innovations of the 21st century will be at the intersection of biology and technology." Silicon Valley-based Verseon now sees itself at this juncture after build Read more at PRNewswire

Global Report on Europe precision medicine Market Size & Share Worth USD 27469 Million, to Record a 10.7% CAGR by 2028 | Europe precision medicine Industry Trends, Segmentation, Analysis & Forecast by Zion Market Research

NEW YORK, May 16, 2022 /PRNewswire/ -- As per Zion Market Research study, The global Europe precision medicine market was worth around USD 14,926.5 million in 2021 and is estimated to grow to about USD 27469 million by 2028, with a compound annual growth rate Read more at PRNewswire

Ibuprofen API Market is Projected to Reach US$ 772.2 Mn by the end of 2029: Future Market Insights, Inc.

Leading market participants of the Ibuprofen API Market elaborated in the report include BASF SE, BIOCAUSE Inc., IOL Chemicals And Pharmaceuticals Limited, SI Group, Inc., Sino-US Zibo Xinhua-Perrigo Pharmaceutical Co., Ltd., Solara Active Pharma Sciences Lim Read more at PRNewswire

[C4P]: 16th International Workshop on Neural-Symbolic Learning and Reasoning (NeSy-2022)

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Global profiling of protein lysine malonylation in Toxoplasma gondii strains of different virulence and genetic backgrounds

Author summary Lysine malonylation has been shown to play important roles in various biological processes in Toxoplasma gondii. Here, we used quantitative liquid chromatography-tandem mass spectrometry (LC-MS/MS) and immuno-affinity purification to test the h Read more at Plos.org

SOPHiA GENETICS SA (SOPH) CEO Jurgi Camblong on Q1 2022 Results - Earnings Call Transcript

SOPHiA GENETICS SA (NASDAQ:NASDAQ:SOPH) Q1 2022 Earnings Conference Call May 10, 2022 8:30 AM ETCompany ParticipantsJennifer Pottage - Head of IRJurgi Camblong - Co-Founder, CEO and... Read more at Seeking Alpha

High DDT resistance without apparent association to kdr and Glutathione-S-transferase (GST) gene mutations in Aedes aegypti population at hotel compounds in Zanzibar

Author summary Available information on mosquito resistance to insecticides is mainly restricted to residential and public areas, whereas commercial settings, such as hotels are overlooked. This may hide the real size of an insecticide resistance problem and Read more at Plos.org

[C4P]: 16th International Workshop on Neural-Symbolic Learning and Reasoning (NeSy-2022)

None
Read more at W3.org

Singular Genomics Systems, Inc. (OMIC) CEO Drew Spaventa on Q1 2022 Results - Earnings Call Transcript

Singular Genomics Systems, Inc. (NASDAQ:NASDAQ:OMIC) Q1 2022 Earnings Conference Call May 10, 2022 4:30 PM ETCompany ParticipantsPhilip Taylor - Investor RelationsDrew Spaventa - Founder... Read more at Seeking Alpha