Study defines small-cell lung cancer subtypes and distinct therapeutic vulnerabilities for each type

Researchers have developed the first comprehensive framework to classify small-cell lung cancer (SCLC) into four unique subtypes, based on gene expression, and have identified potential therapeutic targets for each type in a study. Read more at Science Daily

Mapping from sequence to droplets

Alex Holehouse describes the contributions of Nott et al. to the understanding of the mechanisms of liquidliquid phase separation.
Read more at Nature.com

Nutrition for Precision Health, powered by the All of Us Research Program: Artificial Intelligence for Multimodal Data Modeling and Bioinformatics Center (U54 Clinical Trial Not Allowed)

Funding Opportunity RFA-RM-21-001 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to invite applications for the Artificial Intelligence for Multimodal Data Modeling and Bioinformatics (AIMDMB) Center to join the Nutrition for Precisio Read more at National Institutes of Health

Spontaneous cell fusions amplify genetic diversity within tumors

Scientists generally believe that cancers lack a powerful and important diversification mechanism available to pathogenic microbes - the ability to exchange and recombine genetic material between different cells. However, researchers now demonstrate that this Read more at Science Daily

This startup says its AI can better spot a healthy embryo -- and improve IVF success

With every year, AI is beginning to bring more standardized levels of diagnostic accuracy in medicine. This is true of skin cancer detection, for example... Read more at TechCrunch

Spontaneous cell fusions amplify genetic diversity within tumors, Moffitt researchers say

Scientists generally believe that cancers lack a powerful and important diversification mechanism available to pathogenic microbes - the ability to exchange and recombine genetic material between different cells. However, in a new article published in Nature Read more at EurekAlert

Global $12.26 Billion Plant Genomics Market Analysis and Forecast to 2025 - Increasing Opportunities for Using Next-Generation Sequencing Technologies

DUBLIN, Jan. 22, 2021 /PRNewswire/ -- The "Plant Genomics Market - A Global Market and Regional Analysis: Focus on Product Offering, Technology, Application, Farm Produce, Patent, Government Programs and Funding - Analysis and Forecast, 2020-2025" report has Read more at PRNewswire

Deadly Bacteria Could Be Sharing Antibiotic Resistance Faster Than We Thought

Antibiotics have saved countless lives over the decades. Yet to the pathogens they kill, antibiotics are an ancient foe, one they are already adept at fighting. Read more at ScienceAlert

V-pipe: a computational pipeline for assessing viral genetic diversity from high-throughput data

Abstract Motivation High-throughput sequencing technologies are used increasingly, not only in viral genomics research but also in clinical surveillance and diagnostics. These technologies facilitate the assessment of the genetic diversity in intra-host vir Read more at Oup.com

Sarcoma classification by DNA methylation profiling

Sarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve classifica Read more at Nature.com

RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

The fusion gene RUNX1/RUNX1T1 is oncogenic in acute myeloid leukemia. Here, the authors show that the fusion gene alters the transcriptional landscape of the cells by changing the structure of the 5UTR, altering isoform expression, and controlling the expres Read more at Nature.com

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

After nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that results from slow axon growth. Th Read more at Elifesciences.org

bbeaR: an R package and framework for epitope-specific antibody profiling

Abstract Summary Analysis of epitope-specific antibody repertoires has provided novel insights into the pathogenesis of inflammatory disorders, especially allergies. A novel multiplex immunoassay, termed Bead-Based Epitope Assay (BBEA), was developed to qua Read more at Oup.com

PrInCE: an R/bioconductor package for protein-protein interaction network inference from co-fractionation mass spectrometry data

Abstract Summary We present PrInCE, an R/Bioconductor package that employs a machine-learning approach to infer protein-protein interaction networks from co-fractionation mass spectrometry (CF-MS) data. Previously distributed as a collection of Matlab scrip Read more at Oup.com

MBG: Minimizer-based Sparse de Bruijn Graph Construction

Abstract Motivation De Bruijn graphs can be constructed from short reads efficiently and have been used for many purposes. Traditionally long read sequencing technologies have had too high error rates for de Bruijn graph-based methods. Recently, HiFi reads Read more at Oup.com

New local COVID-19 strain is found in more than one-third of patients at Los Angeles hospital and could be linked to more than 372,000 cases in the city as California becomes first state to top 3 million infections

A new local strain of the novel coronavirus has been found in more than one-third of patients in Los Angeles, a new study finds.
Read more at Yourdestinationnow.com

New genetic disorder affects brain, craniofacial skeleton

Researchers have discovered a new genetic disorder characterized by developmental delays and malformations of the brain, heart, and facial features. Read more at Science Daily

Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels

Microbial conversion of dietary or drug substrates into small bioactive molecules represents a regulatory mechanism by which the gut microbiota alters intestinal physiology. Here, we show that a wide variety of gut bacteria can metabolize the dietary suppleme Read more at Plos.org

31 Companies With Hiring Surges Apply Now!

Although the COVID-19 pandemic continues to significantly impact the global economy, companies are still looking to hire the unemployed. To help employers,... Read more at Glassdoor.com