A Public Website for the Automated Assessment and Validation of SARS-CoV-2 Diagnostic PCR Assays

Abstract Summary Polymerase chain reaction-based assays are the current gold standard for detecting and diagnosing SARS-CoV-2. However, as SARS-CoV-2 mutates, we need to constantly assess whether existing PCR-based assays will continue to detect all known v Read more at Oup.com

TMBIM6/BI-1 contributes to cancer progression through assembly with mTORC2 and AKT activation

TMBIM6, a member of the transmembrane BI-1 motif-containing family of proteins, is overexpressed in many cancer types. Here, the authors show that TMBIM6 regulates AKT activation through mTORC2 assembly and ribosome association and identify an antagonist of T Read more at Nature.com

Biases in bulk: DNA metabarcoding of marine communities and the methodology involved

Abstract With the growing anthropogenic pressure on marine ecosystems, the need for efficient monitoring of biodiversity grows stronger. DNA metabarcoding of bulk samples is increasingly implemented in ecosystem assessments and is more costefficient and less Read more at Wiley.com

Mutation-Simulator: Fine-grained simulation of random mutations in any genome

Abstract Summary Mutation-Simulator allows the introduction of various types of sequence alterations in reference sequences, with reasonable compute-time even for large eukaryotic genomes. Its intuitive system for fine-grained control over mutation rates al Read more at Oup.com

PTGL: extension to graph-based topologies of cryo-EM data for large protein structures

Abstract Summary We provide a software to describe the topology of large protein complexes based mainly on cryo-EM data and stored as macromolecular Crystallographic Information Files (mmCIFs) in the PDB. The software extends the Protein Topology Graph Libr Read more at Oup.com

Mechanistic basis of substrate-O2 coupling within a chitin-active lytic polysaccharide monooxygenase: An integrated NMR/EPR study [Biochemistry]

Lytic polysaccharide monooxygenases (LPMOs) have unique catalytic centers, at which a single copper catalyzes the oxidative cleavage of a glycosidic bond. The mechanism by which LPMOs activate molecular oxygen is key to understanding copper (bio)catalysis but Read more at Pnas.org

LongAGE: defining breakpoints of genomic structural variants through optimal and memory efficient alignments of long reads

Abstract Summary Defining the precise location of structural variations (SVs) at single-nucleotide breakpoint resolution is a challenging problem due to large gaps in alignment. Previously, Alignment with Gap Excision (AGE) enabled us to define breakpoints Read more at Oup.com

New research reveals previously hidden features of plant genomes

An international team has decoded the full genome for the black mustard plant -- research that will advance breeding of oilseed mustard crops and provides a foundation for improved breeding of wheat, canola and lentils. Read more at Science Daily

Sarecycline interferes with tRNA accommodation and tethers mRNA to the 70S ribosome [Biochemistry]

Sarecycline is the first narrow-spectrum tetracycline-class antibiotic that was recently approved by the FDA for the clinical treatment of acne vulgaris. In this work, we determined two (2.8- and 3.0-) X-ray crystal structures of sarecycline bound to the in Read more at Pnas.org

Best Books to Learn Data Science for Beginners and Experts

-
Read more at Geeksforgeeks.org

Within-individual phenotypic plasticity in flowers fosters pollination niche shift

Floral phenotypes impact interactions between plants and pollinators. Here, the authors show that Moricandia arvensis displays discrete seasonal plasticity in floral phenotype, with large, lilac flowers attracting long-tongued bees in spring and small, rounde Read more at Nature.com

A semi-supervised learning framework for quantitative structure-activity regression modelling

Abstract Motivation Quantitative structure-activity regression (QSAR), a type of supervised learning, is increasingly used in assisting the process of preclinical, small molecule drug discovery. Regression models are trained on data consisting of a finite d Read more at Oup.com

GraphQA: Protein Model Quality Assessment using Graph Convolutional Networks

Abstract Motivation Proteins are ubiquitous molecules whose function in biological processes is determined by their 3D structure. Experimental identification of a proteins structure can be time-consuming, prohibitively expensive, and not always possible. A Read more at Oup.com

ResiRole: Residue-Level Functional Site Predictions to Gauge the Accuracies of Protein Structure Prediction Techniques

Abstract Motivation Methods to assess the quality of protein structure models are needed for user applications. To aid with the selection of structure models and further inform the development of structure prediction techniques, we describe the ResiRole met Read more at Oup.com

pocketutils added to PyPI

Adorable little Python code for you to copy or import.
Read more at Pypi.org

Creative block of molecular evolution: Adaptive mutations repeat themselves in tiny crustaceans of Lake Baikal

A group of scientists from Skoltech and the Institute for Information Transmission Problems of RAS (IITP RAS) showed, using Lake Baikal amphipods as an example, that parallel evolution driven by adaptations can be detected at the whole-genome level. The resea Read more at Phys.Org

Multivariate association between brain function and eating disorders using sparse canonical correlation analysis

Eating disorder is highly associated with obesity and it is related to brain dysfunction as well. Still, the functional substrates of the brain associated with behavioral traits of eating disorder are underexplored. Existing neuroimaging studies have explored Read more at Plos.org

Investigating Viruses in Cells Used to Make Vaccines; and Evaluating the Potential Threat Posed by Transmission of Viruses to Humans

Scientific overview on investigating viruses in cells used to make vaccines and evaluating the potential threat posed by transmission of viruses to humans by Principal Investigator Arifa S. Khan, PhD. Read more at FDA.gov

Adaptive mutations repeat themselves in tiny crustaceans of Lake Baikal

(Skolkovo Institute of Science and Technology (Skoltech)) Researchers showed that parallel evolution driven by adaptations can be detected at the whole-genome level. Lake Baikal is home to hundreds of species of endemic amphipods that evolved from several spe Read more at EurekAlert

13 Companies Ramping Up Their Diversity & Inclusion Efforts

While more diverse than in the past, its no secret that corporate America suffers from a lack of diversity and inclusion. Nowadays,...
Read more at Glassdoor.com