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Daily News on Bioinformatics


Study defines small-cell lung cancer subtypes and distinct therapeutic vulnerabilities for each type

2021-01-21 18:21:51 UTC

Study defines small-cell lung cancer subtypes and distinct therapeutic vulnerabilities for each typeResearchers have developed the first comprehensive framework to classify small-cell lung cancer (SCLC) into four unique subtypes, based on gene expression, and have identified potential therapeutic targets for each type in a study. Read more at Science Daily


Mapping from sequence to droplets

2021-01-20 00:00:00 UTC

Alex Holehouse describes the contributions of Nott et al. to the understanding of the mechanisms of liquidliquid phase separation.
Read more at Nature.com


Nutrition for Precision Health, powered by the All of Us Research Program: Artificial Intelligence for Multimodal Data Modeling and Bioinformatics Center (U54 Clinical Trial Not Allowed)

2021-01-21 06:39:03 UTC

placeholder imgFunding Opportunity RFA-RM-21-001 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to invite applications for the Artificial Intelligence for Multimodal Data Modeling and Bioinformatics (AIMDMB) Center to join the Nutrition for Precisio Read more at National Institutes of Health


Spontaneous cell fusions amplify genetic diversity within tumors

2021-01-21 18:20:34 UTC

Spontaneous cell fusions amplify genetic diversity within tumorsScientists generally believe that cancers lack a powerful and important diversification mechanism available to pathogenic microbes - the ability to exchange and recombine genetic material between different cells. However, researchers now demonstrate that this Read more at Science Daily


This startup says its AI can better spot a healthy embryo -- and improve IVF success

2021-01-21 05:57:57 UTC

This startup says its AI can better spot a healthy embryo -- and improve IVF successWith every year, AI is beginning to bring more standardized levels of diagnostic accuracy in medicine. This is true of skin cancer detection, for example... Read more at TechCrunch


Spontaneous cell fusions amplify genetic diversity within tumors, Moffitt researchers say

2021-01-20 05:00:00 UTC

Spontaneous cell fusions amplify genetic diversity within tumors, Moffitt researchers sayScientists generally believe that cancers lack a powerful and important diversification mechanism available to pathogenic microbes - the ability to exchange and recombine genetic material between different cells. However, in a new article published in Nature Read more at EurekAlert


Global $12.26 Billion Plant Genomics Market Analysis and Forecast to 2025 - Increasing Opportunities for Using Next-Generation Sequencing Technologies

2021-01-22 16:15:00 UTC

Global $12.26 Billion Plant Genomics Market Analysis and Forecast to 2025 - Increasing Opportunities for Using Next-Generation Sequencing TechnologiesDUBLIN, Jan. 22, 2021 /PRNewswire/ -- The "Plant Genomics Market - A Global Market and Regional Analysis: Focus on Product Offering, Technology, Application, Farm Produce, Patent, Government Programs and Funding - Analysis and Forecast, 2020-2025" report has Read more at PRNewswire


Deadly Bacteria Could Be Sharing Antibiotic Resistance Faster Than We Thought

2021-01-22 06:11:45 UTC

Deadly Bacteria Could Be Sharing Antibiotic Resistance Faster Than We ThoughtAntibiotics have saved countless lives over the decades. Yet to the pathogens they kill, antibiotics are an ancient foe, one they are already adept at fighting. Read more at ScienceAlert


V-pipe: a computational pipeline for assessing viral genetic diversity from high-throughput data

2021-01-20 00:00:00 UTC

V-pipe: a computational pipeline for assessing viral genetic diversity from high-throughput dataAbstract Motivation High-throughput sequencing technologies are used increasingly, not only in viral genomics research but also in clinical surveillance and diagnostics. These technologies facilitate the assessment of the genetic diversity in intra-host vir Read more at Oup.com


Sarcoma classification by DNA methylation profiling

2021-01-21 00:00:00 UTC

Sarcoma classification by DNA methylation profilingSarcomas are morphologically heterogeneous tumours rendering their classification challenging. Here the authors developed a classifier using DNA methylation data from several soft tissue and bone sarcoma subtypes, which has the potential to improve classifica Read more at Nature.com


RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemia

2021-01-22 00:00:00 UTC

RUNX1/RUNX1T1 mediates alternative splicing and reorganises the transcriptional landscape in leukemiaThe fusion gene RUNX1/RUNX1T1 is oncogenic in acute myeloid leukemia. Here, the authors show that the fusion gene alters the transcriptional landscape of the cells by changing the structure of the 5UTR, altering isoform expression, and controlling the expres Read more at Nature.com


Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-Jun

2021-01-21 00:00:00 UTC

Failures of nerve regeneration caused by aging or chronic denervation are rescued by restoring Schwann cell c-JunAfter nerve injury, myelin and Remak Schwann cells reprogram to repair cells specialized for regeneration. Normally providing strong regenerative support, these cells fail in aging animals, and during chronic denervation that results from slow axon growth. Th Read more at Elifesciences.org


bbeaR: an R package and framework for epitope-specific antibody profiling

2021-01-20 00:00:00 UTC

bbeaR: an R package and framework for epitope-specific antibody profilingAbstract Summary Analysis of epitope-specific antibody repertoires has provided novel insights into the pathogenesis of inflammatory disorders, especially allergies. A novel multiplex immunoassay, termed Bead-Based Epitope Assay (BBEA), was developed to qua Read more at Oup.com


PrInCE: an R/bioconductor package for protein-protein interaction network inference from co-fractionation mass spectrometry data

2021-01-20 00:00:00 UTC

PrInCE: an R/bioconductor package for protein-protein interaction network inference from co-fractionation mass spectrometry dataAbstract Summary We present PrInCE, an R/Bioconductor package that employs a machine-learning approach to infer protein-protein interaction networks from co-fractionation mass spectrometry (CF-MS) data. Previously distributed as a collection of Matlab scrip Read more at Oup.com


MBG: Minimizer-based Sparse de Bruijn Graph Construction

2021-01-20 00:00:00 UTC

MBG: Minimizer-based Sparse de Bruijn Graph ConstructionAbstract Motivation De Bruijn graphs can be constructed from short reads efficiently and have been used for many purposes. Traditionally long read sequencing technologies have had too high error rates for de Bruijn graph-based methods. Recently, HiFi reads Read more at Oup.com


New local COVID-19 strain is found in more than one-third of patients at Los Angeles hospital and could be linked to more than 372,000 cases in the city as California becomes first state to top 3 million infections

2021-01-20 18:01:14 UTC

New local COVID-19 strain is found in more than one-third of patients at Los Angeles hospital and could be linked to more than 372,000 cases in the city as California becomes first state to top 3 million infectionsA new local strain of the novel coronavirus has been found in more than one-third of patients in Los Angeles, a new study finds.
Read more at Yourdestinationnow.com


New genetic disorder affects brain, craniofacial skeleton

2021-01-20 20:10:39 UTC

New genetic disorder affects brain, craniofacial skeletonResearchers have discovered a new genetic disorder characterized by developmental delays and malformations of the brain, heart, and facial features. Read more at Science Daily


Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channels

2021-01-22 14:00:00 UTC

Gut bacteria-derived 5-hydroxyindole is a potent stimulant of intestinal motility via its action on L-type calcium channelsMicrobial conversion of dietary or drug substrates into small bioactive molecules represents a regulatory mechanism by which the gut microbiota alters intestinal physiology. Here, we show that a wide variety of gut bacteria can metabolize the dietary suppleme Read more at Plos.org


31 Companies With Hiring Surges Apply Now!

2021-01-20 21:53:38 UTC

31 Companies With Hiring Surges  Apply Now!Although the COVID-19 pandemic continues to significantly impact the global economy, companies are still looking to hire the unemployed. To help employers,... Read more at Glassdoor.com



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