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Daily News on Population genetics


Rewiring of the ubiquitinated proteome determines ageing in C. elegans

2021-07-28 00:00:00 UTC

Rewiring of the ubiquitinated proteome determines ageing in C. elegansGlobal loss of targeted protein degradation with age results in harmful accumulation of specific proteins in worms.
Read more at Nature.com


Ancient Skulls Show Anglo-Saxon Identity Was More Cultural Than Genetic

2021-07-27 13:00:00 UTC

Ancient Skulls Show Anglo-Saxon Identity Was More Cultural Than GeneticSkeletal evidence shows Britain's ancient Anglo-Saxon society as more genetically diverse than once thought. Language and culture served as a social glue, archaeologists argue, not ancestry. Read more at Discover Magazine


CENTOGENE Appoints Patrice P. Denfle as Chief Scientific Officer to Lead Its Data-Driven Approach to Reinvent Rare Disease Drug Discovery and Development

2021-07-27 10:30:00 UTC

CENTOGENE Appoints Patrice P. Denfle as Chief Scientific Officer to Lead Its Data-Driven Approach to Reinvent Rare Disease Drug Discovery and DevelopmentCAMBRIDGE, Mass. and ROSTOCK, Germany and BERLIN, July 27, 2021 (GLOBE NEWSWIRE) -- Centogene N.V. (Nasdaq: CNTG), a commercial-stage company focused on... Read more at Yahoo Entertainment


Educating the future generation of researchers: A cross-disciplinary survey of trends in analysis methods

2021-07-29 14:00:00 UTC

Educating the future generation of researchers: A cross-disciplinary survey of trends in analysis methodsA quantitative survey of >1 million published research articles reveals that while classical statistical methods remain in widespread use, multivariate statistical and machine-learning approaches have seen a significant increase; statistics curricula should b Read more at Plos.org


Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome

2021-07-28 14:00:00 UTC

Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genomeAuthor summary Many mutations in genomes are deleterious, decreasing fitness in carriers. Popular methods to quantify deleterious mutations model mutations independently while ignoring the correlations between nearby variants. Theory predicts that a deleterio Read more at Plos.org


Role of information in consumers preferences for eco-sustainable genetic improvements in plant breeding

2021-07-29 14:00:00 UTC

Role of information in consumers preferences for eco-sustainable genetic improvements in plant breedingConsumers preferences for products derived from genetic improvements and innovations in plant breeding are often conditioned by technophobia and negative public imaginaries. The current study addresses this issue by analyzing consumers monetary preferences Read more at Plos.org


GlaxoSmithKline's (GSK) CEO Emma Walmsley on Q2 2021 Results - Earnings Call Transcript

2021-07-28 20:31:08 UTC

GlaxoSmithKlineGlaxoSmithKline plc (NYSE:GSK) Q2 2021 Earnings Conference Call July 28, 2021 9:00 AM ETCompany ParticipantsIain Mackay Chief Financial OfficerEmma Walmsley Chief Executive OfficerLuke... Read more at Seeking Alpha


Single caudate neurons encode temporally discounted value for formulating motivation for action

2021-07-30 00:00:00 UTC

Single caudate neurons encode temporally discounted value for formulating motivation for actionThe term temporal discounting describes both choice preferences and motivation for delayed rewards. Here we show that neuronal activity in the dorsal part of the primate caudate head (dCDh) signals the temporally discounted value needed to compute the motiv Read more at Elifesciences.org


BioMarin Pharmaceutical inc (BMRN) Q2 2021 Earnings Call Transcript

2021-07-29 07:32:37 UTC

BioMarin Pharmaceutical inc (BMRN) Q2 2021 Earnings Call TranscriptBMRN earnings call for the period ending June 30, 2021.
Read more at Motley Fool


Dupixent (dupilumab) significantly improved itch and hives in patients with chronic spontaneous urticaria, a step forward in demonstrating the role of type 2 inflammation in these patients

2021-07-29 05:00:00 UTC

Dupixent (dupilumab) significantly improved itch and hives in patients with chronic spontaneous urticaria, a step forward in demonstrating the role of type 2 inflammation in these patientsDupixent (dupilumab) significantly improved itch and hives in patients with chronic spontaneous urticaria, a step forward in demonstrating the role of type ... Read more at Yahoo Entertainment


Opko Health (OPK) Q2 2021 Earnings Call Transcript

2021-07-30 13:02:36 UTC

Opko Health (OPK) Q2 2021 Earnings Call TranscriptOPK earnings call for the period ending June 30, 2021.
Read more at Motley Fool


Dick Lewontin remembered as loyal mentor and friend

2021-07-27 17:00:27 UTC

Dick Lewontin remembered as loyal mentor and friendLate Richard Lewontin remembered as whip-smart, a fierce debater, and an engaged and loyal mentor and friend.
Read more at Harvard School of Engineering and Applied Sciences


How An Altered Strand Of DNA Can Cause Malaria-Spreading Mosquitoes To Self-Destruct

2021-07-28 09:00:24 UTC

How An Altered Strand Of DNA Can Cause Malaria-Spreading Mosquitoes To Self-DestructFor the first time, scientists have shown that a new kind of genetic engineering can crash populations of malaria-spreading mosquitoes.
Read more at NPR


Ancient Skulls Show Anglo-Saxon Identity Was More Cultural Than Genetic

2021-07-27 13:00:00 UTC

Ancient Skulls Show Anglo-Saxon Identity Was More Cultural Than GeneticSkeletal evidence shows Britain's ancient Anglo-Saxon society as more genetically diverse than once thought. Language and culture served as a social glue, archaeologists argue, not ancestry. Read more at Discover Magazine


"To Save Species' Extinction": Scientists Create White Rhino Embyros

2021-07-30 13:38:21 UTC

"To Save SpeciesOne of world's two remaining live specimens -- female Fatu who lives with her mother Najin on Kenya's 90,000-acre Ol Pejeta wildlife conservancy -- provided the eggs for the project, while the sperm used was from two different deceased males. Read more at NDTV News


Computational modelling unveils how epiblast remodelling and positioning rely on trophectoderm morphogenesis during mouse implantation

2021-07-28 14:00:00 UTC

Computational modelling unveils how epiblast remodelling and positioning rely on trophectoderm morphogenesis during mouse implantationUnderstanding the processes by which the mammalian embryo implants in the maternal uterus is a long-standing challenge in embryology. New insights into this morphogenetic event could be of great importance in helping, for example, to reduce human infertility. Read more at Plos.org


Notice of Special Interest (NOSI): Using the Collaborative Cross (CC) Mouse Model for Immunoregulatory and Infectious Disease Research

2021-07-29 07:39:14 UTC

placeholder imgNIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Special Interest (NOSI): Using the Collaborative Cross (CC) Mouse Model for Immunoregulatory and Infectious Disease Research NOT-AI-21-071. NIAID Read more at National Institutes of Health


Ancient Skulls Show Anglo-Saxon Identity Was More Cultural Than Genetic

2021-07-27 13:00:00 UTC

Ancient Skulls Show Anglo-Saxon Identity Was More Cultural Than GeneticSkeletal evidence shows Britain's ancient Anglo-Saxon society as more genetically diverse than once thought. Language and culture served as a social glue, archaeologists argue, not ancestry. Read more at Discover Magazine


Most Americans Have No Idea How Close They are to Poverty, Starvation, and Death

2021-07-27 11:33:44 UTC

Most Americans Have No Idea How Close They are to Poverty, Starvation, and DeathThere are few people left alive today that remember the last time a severe drought that destroyed crops combined with a collapse of the financial system left millions of Americans hungry and homeless, back in the 1930s. Most of us alive today were taught in s Read more at Healthimpactnews.com


An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?

2021-07-27 14:00:00 UTC

An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?Author summary Although many genetic loci have been associated to disease, understanding how these variants impact molecular and cellular functions to impact disease risk have been challenging. Here, we first used blood cells from a large number of individual Read more at Plos.org



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