Rewiring of the ubiquitinated proteome determines ageing in C. elegans

Global loss of targeted protein degradation with age results in harmful accumulation of specific proteins in worms.
Read more at Nature.com

Ancient Skulls Show Anglo-Saxon Identity Was More Cultural Than Genetic

Skeletal evidence shows Britain's ancient Anglo-Saxon society as more genetically diverse than once thought. Language and culture served as a social glue, archaeologists argue, not ancestry. Read more at Discover Magazine

CENTOGENE Appoints Patrice P. Denfle as Chief Scientific Officer to Lead Its Data-Driven Approach to Reinvent Rare Disease Drug Discovery and Development

CAMBRIDGE, Mass. and ROSTOCK, Germany and BERLIN, July 27, 2021 (GLOBE NEWSWIRE) -- Centogene N.V. (Nasdaq: CNTG), a commercial-stage company focused on... Read more at Yahoo Entertainment

Educating the future generation of researchers: A cross-disciplinary survey of trends in analysis methods

A quantitative survey of >1 million published research articles reveals that while classical statistical methods remain in widespread use, multivariate statistical and machine-learning approaches have seen a significant increase; statistics curricula should b Read more at Plos.org

Negative linkage disequilibrium between amino acid changing variants reveals interference among deleterious mutations in the human genome

Author summary Many mutations in genomes are deleterious, decreasing fitness in carriers. Popular methods to quantify deleterious mutations model mutations independently while ignoring the correlations between nearby variants. Theory predicts that a deleterio Read more at Plos.org

Role of information in consumers preferences for eco-sustainable genetic improvements in plant breeding

Consumers preferences for products derived from genetic improvements and innovations in plant breeding are often conditioned by technophobia and negative public imaginaries. The current study addresses this issue by analyzing consumers monetary preferences Read more at Plos.org

GlaxoSmithKline's (GSK) CEO Emma Walmsley on Q2 2021 Results - Earnings Call Transcript

GlaxoSmithKline plc (NYSE:GSK) Q2 2021 Earnings Conference Call July 28, 2021 9:00 AM ETCompany ParticipantsIain Mackay Chief Financial OfficerEmma Walmsley Chief Executive OfficerLuke... Read more at Seeking Alpha

Single caudate neurons encode temporally discounted value for formulating motivation for action

The term temporal discounting describes both choice preferences and motivation for delayed rewards. Here we show that neuronal activity in the dorsal part of the primate caudate head (dCDh) signals the temporally discounted value needed to compute the motiv Read more at Elifesciences.org

BioMarin Pharmaceutical inc (BMRN) Q2 2021 Earnings Call Transcript

BMRN earnings call for the period ending June 30, 2021.
Read more at Motley Fool

Dupixent (dupilumab) significantly improved itch and hives in patients with chronic spontaneous urticaria, a step forward in demonstrating the role of type 2 inflammation in these patients

Dupixent (dupilumab) significantly improved itch and hives in patients with chronic spontaneous urticaria, a step forward in demonstrating the role of type ... Read more at Yahoo Entertainment

Opko Health (OPK) Q2 2021 Earnings Call Transcript

OPK earnings call for the period ending June 30, 2021.
Read more at Motley Fool

Dick Lewontin remembered as loyal mentor and friend

Late Richard Lewontin remembered as whip-smart, a fierce debater, and an engaged and loyal mentor and friend.
Read more at Harvard School of Engineering and Applied Sciences

How An Altered Strand Of DNA Can Cause Malaria-Spreading Mosquitoes To Self-Destruct

For the first time, scientists have shown that a new kind of genetic engineering can crash populations of malaria-spreading mosquitoes.
Read more at NPR

Ancient Skulls Show Anglo-Saxon Identity Was More Cultural Than Genetic

Skeletal evidence shows Britain's ancient Anglo-Saxon society as more genetically diverse than once thought. Language and culture served as a social glue, archaeologists argue, not ancestry. Read more at Discover Magazine

"To Save Species' Extinction": Scientists Create White Rhino Embyros

One of world's two remaining live specimens -- female Fatu who lives with her mother Najin on Kenya's 90,000-acre Ol Pejeta wildlife conservancy -- provided the eggs for the project, while the sperm used was from two different deceased males. Read more at NDTV News

Computational modelling unveils how epiblast remodelling and positioning rely on trophectoderm morphogenesis during mouse implantation

Understanding the processes by which the mammalian embryo implants in the maternal uterus is a long-standing challenge in embryology. New insights into this morphogenetic event could be of great importance in helping, for example, to reduce human infertility. Read more at Plos.org

Notice of Special Interest (NOSI): Using the Collaborative Cross (CC) Mouse Model for Immunoregulatory and Infectious Disease Research

NIH Funding Opportunities and Notices in the NIH Guide for Grants and Contracts: Notice of Special Interest (NOSI): Using the Collaborative Cross (CC) Mouse Model for Immunoregulatory and Infectious Disease Research NOT-AI-21-071. NIAID Read more at National Institutes of Health

Ancient Skulls Show Anglo-Saxon Identity Was More Cultural Than Genetic

Skeletal evidence shows Britain's ancient Anglo-Saxon society as more genetically diverse than once thought. Language and culture served as a social glue, archaeologists argue, not ancestry. Read more at Discover Magazine

Most Americans Have No Idea How Close They are to Poverty, Starvation, and Death

There are few people left alive today that remember the last time a severe drought that destroyed crops combined with a collapse of the financial system left millions of Americans hungry and homeless, back in the 1930s. Most of us alive today were taught in s Read more at Healthimpactnews.com

An autoimmune disease risk variant: A trans master regulatory effect mediated by IRF1 under immune stimulation?

Author summary Although many genetic loci have been associated to disease, understanding how these variants impact molecular and cellular functions to impact disease risk have been challenging. Here, we first used blood cells from a large number of individual Read more at Plos.org