MSGFPlus (MSGF+ or MSGFPlus) is a tool to identify peptide from tandem mass spectra (MS/MS) data. The MSGFPlus algorithm scores MS/MS spectra against a protein sequence database to identify peptides. MSGFPlus algorithm is optimal for various combinations of fragmentation methods, instruments, enzymes, and experimental protocols. See also an R interface for MSGFPlus and MSGFgui.
Proteomics experiment; Protein expression; Small molecules
Kim S, Pevzner PA "MS-GF+ makes progress towards a universal database search tool for proteomics." Nat Commun 2014 https://doi.org/10.1038/ncomms6277
PMID: 25358478
PMCID: PMC5036525
Kim S, Gupta N, Pevzner PA "Spectral probabilities and generating functions of tandem mass spectra: a strike against decoy databases." J Proteome Res, 2008 https://doi.org/10.1021/pr8001244
PMID: 18597511
PMCID: PMC2689316
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