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COVID-19 Scientific Facts

COVID-19 Scientific Facts



Lukassen, S., Chua, R. L., Trefzer, T., Kahn, N. C., Schneider, M. A., Muley, T., Winter, H., Meister, M., Veith, C., Boots, A. W., Hennig, B. P., Kreuter, M., Conrad, C., Eils, R. "SARS-CoV-2 receptor ACE2 and TMPRSS2 are predominantly expressed in a transient secretory cell type in subsegmental bronchial branches." doi: 10.1101/2020.03.13.991455. — Posted: 2020-03-14

Yuan, M., Wu, N. C., Zhu, X., Lee, C.-C. D., So, R. T. Y., Lv, H., Mok, C. K. P., Wilson, I. A. "A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2 and SARS-CoV." doi: 10.1101/2020.03.13.991570. — Posted: 2020-03-14

D'Annessa, I., Marchetti, F., Colombo, G. "Differential Antibody Recognition by Novel SARS-CoV-2 and SARS-CoV Spike Protein Receptor Binding Domains: Mechanistic Insights." doi: 10.1101/2020.03.13.990267. — Posted: 2020-03-14

Kim, D., Lee, J.-Y., Yang, J.-S., Kim, J. W., Kim, V. N., Chang, H. "The architecture of SARS-CoV-2 transcriptome." doi: 10.1101/2020.03.12.988865 . — Posted: 2020-03-14

Peer reviewed publications

Kristian G Andersen, Andrew Rambaut, W Ian Lipkin, Edward C Holmes, Robert F Garry (2020). "The proximal origin of SARS-CoV-2." Nat Med doi: 10.1038/s41591-020-0820-9.

Zhao S, Cao P, Gao D, Zhuang Z, Cai Y, Ran J, Chong MKC, Wang K, Lou Y, Wang W, Yang L, He D, Wang MH (2020). "Serial interval in determining the estimation of reproduction number of the novel coronavirus disease (COVID-19) during the early outbreak." J Travel Med. 2020 Mar 12:taaa033. doi: 10.1093/jtm/taaa033. Epub ahead of print. PMID: 32163140.

Choi SC, Ki M (2020). "Estimating the reproductive number and the outbreak size of Novel Coronavirus disease (COVID-19) using mathematical model in Republic of Korea." Epidemiol Health. 2020 Mar 12:e2020011. doi: 10.4178/epih.e2020011. Epub ahead of print. PMID: 32164053.

Kucharski AJ, Russell TW, Diamond C, Liu Y, Edmunds J, Funk S, Eggo RM; Centre for Mathematical Modelling of Infectious Diseases COVID-19 working group (2020). "Early dynamics of transmission and control of COVID-19: a mathematical modelling study." Lancet Infect Dis. 2020 Mar 11:S1473-3099(20)30144-4. doi: Doi: 10.1016/S1473-3099(20)30144-4. Epub ahead of print.

Xiaolu Tang, Changcheng Wu, Xiang Li, Yuhe Song, Xinmin Yao, Xinkai Wu, Yuange Duan, Hong Zhang, Yirong Wang, Zhaohui Qian, Jie Cui, Jian Lu (2020). "On the origin and continuing evolution of SARS-CoV-2." National Science Review, nwaa036. Published: 03 March 2020. Doi: 10.1093/nsr/nwaa036.

Huang C, Wang Y, Li X, et al. (2020) "Clinical Features of Patients Infected With 2019 Novel Coronavirus in Wuhan, China." Lancet. 2020;395(10223):497–506. doi: 10.1016/s0140-6736(20)30183-5

Cheng AC, Williamson DA (2020). "An outbreak of COVID-19 caused by a new coronavirus: what we know so far." Med J Aust. 2020 Mar 8. doi: 10.5694/mja2.50530. Epub ahead of print. PMID: 32146721.

Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL (2020). "A pneumonia outbreak associated with a new coronavirus of probable bat origin." Nature. 2020 Feb 3. doi: 10.1038/s41586-020-2012-7. Epub ahead of print. PMID: 32015507.

Salata C, Calistri A, Parolin C, Palù G (2019). "Coronaviruses: a paradigm of new emerging zoonotic diseases." Pathog Dis. 2019 Dec 1;77(9):ftaa006. doi: 10.1093/femspd/ftaa006. PMID: 32065221.

Retracted / unpublished

Prashant Pradhan, Ashutosh Kumar Pandey, Akhilesh Mishra, Parul Gupta, Praveen Kumar Tripathi, Manoj Balakrishnan Menon, James Gomes1, Perumal Vivekanandan and Bishwajit Kundu. "Uncanny similarity of unique inserts in the 2019-nCoV spike protein to HIV-1 gp120 and Gag." BioRxiv 10.1101/2020.01.30.927871

Botao Xiao, Lei Xiao (Feb 2020). "The possible origins of 2019-nCoV coronavirus." Link


Wang C, Liu Z, Chen Z, Huang X, Xu M, He T, Zhang Z (2020). "The establishment of reference sequence for SARS-CoV-2 and variation analysis." J Med Virol. 2020 Mar 13. doi: 10.1002/jmv.25762. Epub ahead of print. PMID: 32167180.

Sah R, Rodriguez-Morales AJ, Jha R, Chu DKW, Gu H, Peiris M, Bastola A, Lal BK, Ojha HC, Rabaan AA, Zambrano LI, Costello A, Morita K, Pandey BD, Poon LLM (2020). "Complete Genome Sequence of a 2019 Novel Coronavirus (SARS-CoV-2) Strain Isolated in Nepal." Microbiol Resour Announc. 2020 Mar 12;9(11):e00169-20. doi: 10.1128/MRA.00169-20. PMID: 32165386.

Li C, Yang Y, Ren L (2020). "Genetic evolution analysis of 2019 novel coronavirus and coronavirus from other species." Infect Genet Evol. 2020 Mar 10:104285. doi: 10.1016/j.meegid.2020.104285. Epub ahead of print. PMID: 32169673.

Transmission details such as R0, mortality rate, recovery


Comparison of symptoms, COVID-19, influenza, cold

Links to official genomic resources

China National Center for Bioinformation 2019 Novel Coronavirus Resource (2019nCoVR)

Protocols sharing by to accelerate COVID-19 research. This is a method development community site.

Cell Press selected paper on COVID-19


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