Bridger is a tool for de novo assembly of RNA-seq full-length transcriptome data. The Bridger algorithm adapts schemes used in Cufflink and Trinity. It can handle paired-end reads and multiple insert sizes. The sensitivity and specificity are similar to Cufflink. Bridger runs faster and requires less physical memory than several other assembly tools.
Transcriptomics; Sequence assembly
Chang Z, Li G, Liu J, Zhang Y, Ashby C, Liu D, Cramer CL, Huang X "Bridger: a new framework for de novo transcriptome assembly using RNA-seq data." Genome Biol. 2015 Feb 11;16:30. https://doi.org/10.1186/s13059-015-0596-2
PMID: 25723335
PMCID: PMC4342890
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