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DENDRO
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DENDRO

DENDRO (Dna based EvolutioNary tree preDiction by scRna-seq technOlogy) is a tool to profile genetic heterogeneity and to detect subclones in single-cell RNA-seq (scRNA-seq) data. The DENDRO algorithm clusters subclones and computes a related phylogenetic tree.



DENDRO

DENDRO (Dna based EvolutioNary tree preDiction by scRna-seq technOlogy) is a tool to profile genetic heterogeneity and to detect subclones in single-cell RNA-seq (scRNA-seq) data. The DENDRO algorithm clusters subclones and computes a related phylogenetic tree.

Topic

RNA-seq; Cell biology; Genetics

Details

  • Operation: Gene expression analysis; RNA-Seq analysis; Expression profile clustering
  • Software interface: Command-line user interface
  • Language: R
  • Operating system: Linux; Mac OS X; Microsoft Windows
  • License: GNU General Public License v3
    • Cost: Free
  • Version name: 0.2.1
  • Credit: The National Institutes of Health (NIH).
  • Contact: zhouzilu _at_ pennmedicine.upenn.edu | nzh _at_ wharton.upenn.edu | zhouzilu _at_ pennmedicine.upenn.edu
  • Collection: -

Publications

Zhou Z, Xu B, Minn A, Zhang NR "DENDRO: Genetic Heterogeneity Profiling and Subclone Detection by Single-Cell RNA Sequencing" Genome Biol. 2020 Jan 14;21(1):10. https://doi.org/10.1186/s13059-019-1922-x
PMID: 31937348
PMCID: PMC6961311


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