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DESCEND

DESCEND

DESCEND is a tool to deconvolve gene expression in single-cell RNA-seq (scRNA-seq) counts. The DESCEND algorithm uses technical noise model and unique molecular identifiers (UMI).

Topic

RNA-Seq; Gene expression

Details

  • Operation: Differential gene expression analysis
  • Software interface: Command-line user interface
  • Language: R
  • Operating system: Linux; Mac OS X; Microsoft Windows
  • License: GNU General Public License v>=2
  • Cost: Free
  • Version name: 0.0.0.9000
  • Credit: National Institutes of Health (NIH).
  • Contact: Jingshu Wang jingshuw _at_ upenn.edu | nzh _at_ wharton.upenn.edu
  • Collection: -

Publications

Wang J, Huang M, Torre E, Dueck H, Shaffer S, Murray J, Raj A, Li M, Zhang NR "Gene Expression Distribution Deconvolution in Single-Cell RNA Sequencing" Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6437-E6446. https://doi.org/10.1073/pnas.1721085115
PMID: 29946020
PMCID: PMC6048536


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