DESCEND is a tool to deconvolve gene expression in single-cell RNA-seq (scRNA-seq) counts. The DESCEND algorithm uses technical noise model and unique molecular identifiers (UMI).
RNA-Seq; Gene expression
Wang J, Huang M, Torre E, Dueck H, Shaffer S, Murray J, Raj A, Li M, Zhang NR "Gene Expression Distribution Deconvolution in Single-Cell RNA Sequencing" Proc Natl Acad Sci U S A. 2018 Jul 10;115(28):E6437-E6446. https://doi.org/10.1073/pnas.1721085115
PMID: 29946020
PMCID: PMC6048536
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