HoneyBADGER (hidden Markov model integrated Bayesian approach for detecting CNV and LOH events from single-cell RNA-seq data) is a tool to identify copy number variation (CNV) and loss of heterozygosity (LOH) in single-cell RNA-seq (scRNA-seq) data. The HoneyBADGER algorithm can also reconstruct subclonal architecture.
RNA-Seq; Gene expression
Fan Jean, Lee Hae-Ock, Lee Soohyun, Ryu Da-eun, Lee Semin, Xue Catherine, Kim Seok Jin, Kim Kihyun, Barkas Nikolaos, Park Peter J., Park Woong-Yang, Kharchenko Peter V. "Linking transcriptional and genetic tumor heterogeneity through allele analysis of single-cell RNA-seq data" bioRxiv https://doi.org/10.1101/gr.228080.117
PMID: 29898899
PMCID: PMC6071640
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