MSigDB (The Molecular Signatures Database) is a database comprising of annotated gene sets for use by gene set enrichment analysis (GSEA) tools. The web-based tool allows keyword search, browsing by collection, name, and annotation, computation of overlaps, categorizing, and viewing of expression profiles as well as downloading. A pure Mouse and human version are available in R format at Walter+Eliza Hall Institute of Medical Research (see links).
Gene-set enrichment analysis
Liberzon A, Subramanian A, Pinchback R, Thorvaldsdottir H, Tamayo P, Mesirov JP "Molecular signatures database (MSigDB) 3.0." Bioinformatics. 2011 Jun 15;27(12):1739-40. Epub 2011 May 5. https://doi.org/10.1093/bioinformatics/btr260
PMID: 21546393
PMCID: PMC3106198
Liberzon A "A description of the Molecular Signatures Database (MSigDB) Web site." Methods Mol Biol. 2014;1150:153-60. https://doi.org/10.1007/978-1-4939-0512-6_9
PMID: 24743996
Liberzon A, Birger C, Thorvaldsdóttir H, Ghandi M, Mesirov JP, Tamayo P "The Molecular Signatures Database (MSigDB) hallmark gene set collection." Cell Syst. 2015 Dec 23;1(6):417-425. https://doi.org/10.1016/j.cels.2015.12.004
PMID: 26771021
PMCID: PMC4707969
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