UNCURL is a tool to preprocess non-negative matrix factorization for single-cell RNA-seq (scRNA-seq) data. The UNCURL algorithm is able to include prior knowledge.
RNA-seq; Gene expression; Cell biology; Developmental biology
Mukherjee S, Zhang Y, Fan J, Seelig G, Kannan S "Scalable preprocessing for sparse scRNA-seq data exploiting prior knowledge." Bioinformatics. 2018 Jul 1;34(13):i124-i132. https://doi.org/10.1093/bioinformatics/bty293
PMID: 29949988
PMCID: PMC6022691
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