ZIFA (Zero Inflated Factor Analysis) is a tool to reduce dimensionality in single-cell RNA-seq data. The ZIFA algorithm also has models for characteristics of dropouts.
RNA-seq; Gene expression
Pierson E, Yau C "ZIFA: Dimensionality reduction for zero-inflated single-cell gene expression analysis." Genome Biol. 2015 Nov 2;16:241. https://doi.org/10.1186/s13059-015-0805-z
PMID: 26527291
PMCID: PMC4630968
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