clonealign is a tool for the assignment of expression profiles to cancer clones in single-cell RNA-seq and DNA sequencing data. The clonealign algorithm uses a probabilistic, reparametrization gradient variational inference, approach to map expression profiles to copy number profiles.
Gene expression; RNA-seq
Campbell KR, Steif A, Laks E, Zahn H, Lai D, McPherson A, Farahani H, Kabeer F, O'Flanagan C, Biele J, Brimhall J, Wang B, Walters P, Consortium I, Bouchard-Cote A, Aparicio S, Shah SP "clonealign: statistical integration of independent single-cell RNA and DNA sequencing data from human cancers." Genome Biol. 2019 Mar 12;20(1):54. https://doi.org/10.1186/s13059-019-1645-z
PMID: 30866997
PMCID: PMC6417140
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