scDC (single cell differential composition) is a tool package containing a collection of functions for the analysis of single-cell RNA-seq (scRNA-seq) data. It analyses differential cell-type composition using bootstrap resampling to estimate the uncertainty in cell-type proportions and compute confidence intervals.
RNA-seq; Gene expression
Cao Y, Lin Y, Ormerod JT, Yang P, Yang JYH, Lo "scDC: single cell differential composition analysis." BMC Bioinformatics. 2019 Dec 24;20(Suppl 19):721. https://doi.org/10.1186/s12859-019-3211-9
PMID: 31870280
PMCID: PMC6929335
Kim T, Chen IR, Lin Y, Wang AY, Yang JYH, Yang P "Impact of similarity metrics on single-cell RNA-seq data clustering." Brief Bioinform. 2019 Nov 27;20(6):2316-2326. https://doi.org/10.1093/bib/bby076
PMID: 30137247
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