wot (Waddington-OT) is a tool to analyze Optimal-Transport of single-cell expression in RNA-seq data sets. The wot algorithm applies time-course data to compute the probability distributions of cells.
RNA-seq; Gene expression
Schiebinger G, Shu J, Tabaka M, Cleary B, Subramanian V, Solomon A, Gould J, Liu S, Lin S, Berube P, Lee L, Chen J, Brumbaugh J, Rigollet P, Hochedlinger K, Jaenisch R, Regev A, Lander ES "Optimal-Transport Analysis of Single-Cell Gene Expression Identifies Developmental Trajectories in Reprogramming." Cell. 2019 Feb 7;176(4):928-943.e22. Jan 31. https://doi.org/10.1016/j.cell.2019.01.006
PMID: 30712874
PMCID: PMC6402800
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