MECAT is a tool for de novo assembly of long single molecule sequenced reads (e.g. PacBio). The tool implemented a pseudolinear alignment scoring algorithm to remove unnecessary alignments based on distance difference factors (DDFs) to score matched k-mer pairs. Large genomes can be assembled on a single computer using this tool.
Sequence assembly
Xiao CL, Chen Y, Xie SQ, Chen KN, Wang Y, Han Y, Luo F, Xie Z "MECAT: fast mapping, error correction, and de novo assembly for single-molecule sequencing reads." Nat Methods. 2017 Nov;14(11):1072-1074. 18. https://doi.org/10.1038/nmeth.4432
PMID: 28945707
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