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CANOES is a tool for detection of copy number variation (CNV) in whole-genome exome sequencing data. The CANOES algorithm uses the negative binomial distribution to model read counts and a regression-based method on user-selected reference samples.


Genetic variation


  • Operation: Variation detection
  • Software interface: Command-line user interface
  • Language: R
  • Operating system: Linux; Mac OS X; Microsoft Windows
  • License: Not stated
  • Cost: Free
  • Version name: -
  • Credit: Department of Systems Biology at Columbia University, Columbia Genome Center, National Institutes of Health (NIH); National Heart, Lung and Blood Institute (NHLBI), Pediatric Cardiac Genomics Consortium, John S. LaDue Memorial Fellowship at Harvard Medical School
  • Contact: Daniel Backenroth db2175 _at_ | Yufeng Shen ys2411 _at_
  • Collection: -


Daniel Backenroth, Jason Homsy, Laura R. Murillo, Joe Glessner, Edwin Lin, Martina Brueckner, Richard Lifton, Elizabeth Goldmuntz, Wendy K. Chung, Yufeng Shen "CANOES: detecting rare copy number variants from whole exome sequencing data." Nucleic Acids Research, Volume 42, Issue 12, 8 July 2014, Page e97
PMID: 24771342
PMCID: PMC4081054

Download and documentation

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